ReviewEvidence-based complementary and alternative medicine : eCAM2020
Effects of Herbal Mouthwashes on Plaque and Inflammation Control for Patients with Gingivitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Review in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- The impact of scaling and root planning combined with mouthwash during pregnancy on preterm birth and low birth weight: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Effectiveness of herbal oral care products in reducing dental plaque and gingivitis: an overview of systematic reviews.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2024Pooled it
- Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental healthcare providers.The Cochrane database of systematic reviews · 2022Pooled it
- Comparative effectiveness of Propolis with chlorhexidine mouthwash on gingivitis - a randomized controlled clinical study.BMC complementary medicine and therapies · 2024Trial
- Efficacy of Moraceae with chlorhexidine mouthwash on the microbial flora of critically ill intubated patients: a randomized controlled pilot study.Scientific reports · 2022Trial
- A randomized, placebo-controlled clinical trial evaluating of a mouthwash containing Sambucus williamsii var. coreana extract for prevention of gingivitits.Scientific reports · 2022Trial
- Differential Gene Expression ofInternational journal of molecular sciences · 2025Article
- Article
- Propolis mouthwashes efficacy in managing gingivitis and periodontitis: a systematic review of the latest findings.BDJ open · 2025Article
- Based on network pharmacology and molecular docking to explore the potential mechanism of shikonin in periodontitis.BMC oral health · 2024Article
- Preparation and Evaluation of the Biological Properties of Ethanolic Extract of Red Clover: An In Vitro Study.Cureus · 2024Article
- Ingredients in Commercially Available Mouthwashes.International dental journal · 2024Review
- Antimicrobial Mouthwashes: An Overview of Mechanisms-What Do We Still Need to Know?International dental journal · 2023Review
- Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness.Journal of personalized medicine · 2023Review
- The Antimicrobial Activity of Curcumin and Xanthohumol on Bacterial Biofilms Developed over Dental Implant Surfaces.International journal of molecular sciences · 2023Article
- Article
- Preliminary Evaluation of a NitrAdine-Based Brushing Solution for Patients Suffering from Gingivitis: A Prospective Clinical Case-Control Study.European journal of dentistry · 2022Article
- Evidence on the Use of Mouthwash for the Control of Supragingival Biofilm and Its Potential Adverse Effects.Antibiotics (Basel, Switzerland) · 2022Review
- Antimicrobial Effects ofNutrients · 2021Article
- Clinical and microbial evaluation of mouthwash containingJournal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate the overall effects of herbal mouthwashes as supplements to daily oral hygiene on plaque and inflammation control compared with placebos and chlorhexidine (CHX) mouthwashes in the treatment of gingivitis.
methodsPubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and grey literature databases were searched. Only randomised controlled trials (RCTs) comparing herbal mouthwashes with placebos or CHX in the daily oral hygiene of patient with gingivitis were included to compare the effect of different mouthwashes on plaque and inflammation control.
resultsA total of 13 studies satisfied the eligibility criteria, and 11 studies were included in meta-analyses. Significant differences were observed in favour of herbal mouthwashes compared with placebos in both plaque- and inflammation-related indices (Quigley-Hein Plaque Index, QHPI: WMD = -0.61, 95% CI (-0.80, -0.42),
conclusionsHerbal mouthwashes have potential benefits in plaque and inflammation control as supplements to the daily oral hygiene of patients with gingivitis. Although no difference was observed between herbal and CHX mouthwashes in the selected studies, further high-quality RCTs are needed for more firm support before advising patients with gingivitis about whether they can use herbal mouthwashes to substitute for CHX mouthwashes or not (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.