Evidence map›Paper›PMID 32419604›Full record

ReviewEpigenetics2020

Ten-eleven translocation proteins and their role beyond DNA demethylation - what we can learn from the fly.

Joy N Ismail, Mirna Ghannam, Amani Al Outa, Felice Frey, Margret Shirinian

Abstract readReview
In one paragraph

Review in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Insights on SNPs of Human Activation-Induced Cytidine Deaminase AID.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. eNeuro
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joy N IsmailDepartment of Experimental pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut , Beirut, Lebanon.ORCID 0000-0002-7128-7040
Mirna GhannamDepartment of Experimental pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut , Beirut, Lebanon.
Amani Al OutaDepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut , Beirut, Lebanon.
Felice FreyDepartment of Experimental pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut , Beirut, Lebanon.ORCID 0000-0001-9002-154X
Margret ShirinianDepartment of Experimental pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut , Beirut, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ten-eleven Translocation (TET) proteins have emerged as a family of epigenetic regulators that are important during development and have been implicated in various types of cancers. TET is a highly conserved protein that has orthologues in almost all multicellular organisms. Here, we review recent literature on the novel substrate specificity of this family of DNA 5-methylcytosine demethylases on DNA 6-methyladenine and RNA 5-methylcytosine that were first identified in the invertebrate model

Indexed as

DNA MethylationEpigenesis, GeneticAnimalsDrosophilaDrosophila ProteinsGene Expression Regulation, DevelopmentalMixed Function OxygenasesDrosophila ProteinsMixed Function Oxygenasescancer biologyDNA demethylationDrosophilaepigeneticsneuroscience

Identifiers

PMID32419604
PMCPMC7595634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.