ReviewAnaesthesiology intensive therapy2020
The opioid crisis in North America: facts and future lessons for Europe.
Review in Anaesthesiology intensive therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06912399 (Effect of Transauricular Vagus Nerve Stimulation on Postoperative Pain Management in Video Assisted Thoracic Surgery), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Transauricular Vagus Nerve Stimulation on Postoperative Pain Management in Video Assisted Thoracic Surgery: a Randomized Controlled Clinical Trial
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Harms associated with injecting in public spaces: a global systematic review and meta-analysis.The International journal on drug policy · 2025Pooled it
- Effect of Transauricular Vagus Nerve Stimulation on Rebound Pain After Ropivacaine Single Injection Femoral Nerve Block for Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial.Journal of pain research · 2022Trial
- Effectiveness of Fascia Iliaca Compartment Block after Elective Total Hip Replacement: A Prospective, Randomized, Controlled Study.International journal of environmental research and public health · 2021Trial
- Real-world comparative effects of slow-release oral morphine vs. methadone on healthcare use for opioid use disorder: A population-based target trial emulation.Addiction (Abingdon, England) · 2026Article
- "Once I started going… I had this central wheel hub": Drivers of overdose prevention center engagement and connections to care in Rhode Island.The International journal on drug policy · 2026Article
- Opioid use after breast cancer in Denmark: a nationwide study of social and clinical factors.Journal of the National Cancer Institute · 2026Article
- Exploring Non-Pharmacological Interventions as Part of Multimodal Management to Prevent Opioid Misuse in Adults Prescribed Opioids for Chronic Pain.Journal of clinical medicine · 2026Review
- Changing trends in drug overdose mortality in Spain, 2001-2022.Addiction (Abingdon, England) · 2026Observational
- Assessing the disease burden of opioid use disorder in western europe: trends, gender differences, and future directions.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Rethinking postoperative opioid use in pediatric appendectomy: a cross-cultural comparison between Japan and North America.Journal of anesthesia · 2026Article
- North American and European practices for opioid-sparing and opioid-free anaesthesia: a cross-sectional survey.BJA open · 2025Article
- Beyond Opioids: A Review of Suzetrigine for Acute Pain Management.International journal of molecular sciences · 2025Review
- Mental health behaviors and suicide risk among White and Black adults with Opioid Use Disorder.Social science & medicine (1982) · 2025Article
- Fentanyl-Antibody Interaction as a Novel Strategy against Opiates and Opioids Abuse.Journal of medicinal chemistry · 2025Review
- Article
- Impact of opioid abuse on oral health: a retrospective cohort study.Frontiers in oral health · 2025Article
- Postoperative Opioid Administration and Prescription Practices Following Hysterectomy in Two Tertiary Care Centres: A Comparative Cohort Study between Canada and Austria.Journal of clinical medicine · 2024Article
- Spinal Cord Stimulation for Intractable Chronic Limb Ischemia: A Narrative Review.Journal of cardiovascular development and disease · 2024Review
- Bridging the Gap in Harm Reduction Using Mobile Overdose Response Services (MORS) in the Context of the COVID-19 Pandemic: A Qualitative Study.Journal of urban health : bulletin of the New York Academy of Medicine · 2024Article
- The Imperative of Regulation: The Co-creation of a Medical and Non-medical US Opioid Crisis.Psychoactives · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past two decades, opioid-related hospitalizations and deaths in North America have reached the level of a public health emergency. Initially, the epidemic of opioid misuse was largely driven by pharmaceutical companies and initiated by their spread of misinformation, which led physicians to engage in overzealous prescribing behaviour. This was followed by significant harms as deaths related to overdoses on prescription and illicit opioids rose steadily throughout the 1990s and early 2000s. This review examines the historical context of the opioid crisis in the United States and Canada, the role of physicians, the contributions of the pharmaceutical industry and the evolution of the epidemic in response to the introduction of highly potent synthetic opioids now recognized as the main culprits in opioid overdose and death. This article further explores the evidence surrounding the effectiveness of various treatment strategies and harm-reduction interventions designed to curtail the morbidity and mortality associated with opioid use. Finally, the magnitude of the opioid epidemic in North America is compared to that in European countries. This paper describes the differences in North American and European experiences with opioid overdose and the evidence-based approaches that can be implemented to reduce the mortality and morbidity linked to opioids while simultaneously ensuring adequate pain control for patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.