Evidence map›Paper›PMID 32419399›Full record

ArticleJournal of Korean medical science2020

Predicting First-Year Growth in Response to Growth Hormone Treatment in Prepubertal Korean Children with Idiopathic Growth Hormone Deficiency: Analysis of Data from the LG Growth Study Database.

Won Kyoung Cho, Moon Bae Ahn, Eun Young Kim, Kyoung Soon Cho, Min Ho Jung, Byung Kyu Suh

2 registry-linked trialsAbstract read
In one paragraph

Article in Journal of Korean medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01604395 recruitingnot on this map

An Open, Multi-center, Prospective and Retrospective Observational Study to Evaluate the Long-term Safety and Effectiveness of Growth Hormone (Eutropin Inj. / Eutropin Plus Inj.) Treatment With GHD, TS, CRF, SGA, ISS and PWS in Children

TypeobservationalSponsorLG ChemRan2012 to 2032Enrolled6,000ConditionsGrowth Hormone Deficiency, Turner Syndrome, Chronic Renal Failure, Small for Gestational Age
NCT06103513 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

A Randomized Clinical Trial of Two Different Initial Growth Hormone Doses in Children With Growth Hormone Deficiency in the First Year of Treatment

TypeinterventionalSponsorNorthwell HealthRan2023 to 2025Enrolled50ConditionsGrowth Disorders, Growth Failure, Growth Hormone Treatment, GrowthArmsSomatropin
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Observational
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Won Kyoung ChoDepartment of Pediatrics, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-0918-0565
Moon Bae AhnDepartment of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-1108-2788
Eun Young KimDepartment of Statistics & Data Monitoring, Life Science R&D, LG Chem, Ltd., Seoul, Korea.ORCID https://orcid.org/0000-0002-4975-1986
Kyoung Soon ChoDepartment of Pediatrics, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-0212-0992
Min Ho JungDepartment of Pediatrics, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0001-5188-7041
Byung Kyu SuhDepartment of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. suhbk@catholic.ac.kr.ORCID https://orcid.org/0000-0003-1971-0232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe first-year growth in response to growth hormone (GH) treatment seems to be the most important factor in determining the overall success of GH treatment.

methodsData from children (n = 345) who were in the LG Growth Study Database were used to develop a model. All subjects had been diagnosed with idiopathic growth hormone deficiency (GHD) and presented in a prepubertal state during the first year of GH treatment.

resultsThe Δheight standard deviation score (SDS) during 1st year of GH treatment was correlated positively with weight-SDS (β = 0.304,

conclusionThe present model to predict first-year response to GH treatment might allow more tailored and personalized GH treatment in Korean prepubertal children with idiopathic GHD.

trial registrationClinicalTrials.gov Identifier: NCT01604395.

Indexed as

Body Mass IndexBody WeightChildChild, PreschoolFemaleGrowth DisordersHuman Growth HormoneHumansMaleRegression AnalysisRepublic of KoreaTreatment OutcomeHuman Growth HormoneGrowth Hormone DeficiencyPredictionTreatment

Identifiers

PMID32419399
PMCPMC7234860

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.