Evidence map›Paper›PMID 32419314›Full record

ReviewEMBO reports2020

Calcium regulation of stem cells.

Hans-Willem Snoeck

Open access · bronzeAbstract readReview
In one paragraph

Review in EMBO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Gene expression regulation by CaCellular & molecular biology letters · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Oxytocin, the Love Hormone, in Stem Cell Differentiation.Current issues in molecular biology · 2024
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Hans-Willem SnoeckColumbia Center of Human Development, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-8375-995X
Columbia University Irving Medical Center · US

Funding

Mitochondrial Regulation of Hematopoietic Stem CellsR01HL135039 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2017 to 2025
$4.5M
EVALUATION OF OSTEOPOROSIS PREVENTION IN THE ELDERLYR01AG012262 · NIA · DARTMOUTH COLLEGE · PI TOSTESON, ANNA N. A. · 1995 to 2006
$3.2M
Mitochondrial Maintenance Mechanisms of Stem Cells and AgingR01AG055910 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2017 to 2021
$2.0M
HHS|NIH|National Institute on Aging (NIA) 1R01 AG055910NHLBI NIH HHS R01 HL135039NIA NIH HHS R01 AG012262NIA NIH HHS R01 AG055910
6 · The paper itself

Abstract

Pluripotent and post-natal, tissue-specific stem cells share functional features such as the capacity to differentiate into multiple lineages and to self-renew, and are endowed with specific cell maintenance mechanism as well as transcriptional and epigenetic signatures that determine stem cell identity and distinguish them from their progeny. Calcium is a highly versatile and ubiquitous second messenger that regulates a wide variety of cellular functions. Specific roles of calcium in stem cell niches and stem cell maintenance mechanisms are only beginning to be explored, however. In this review, I discuss stem cell-specific regulation and roles of calcium, focusing on its potential involvement in the intertwined metabolic and epigenetic regulation of stem cells.

Indexed as

CalciumEpigenesis, GeneticCell DifferentiationStem CellsCalciumcalciumepigeneticsmetabolismpluripotent stem cellspost-natal stem cells

Identifiers

PMID32419314
PMCPMC7271657
OpenAlexW3024509547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.