ArticleInternational ophthalmology2020
Does systemic inflammation play a role in patients with pterygium?
Article in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis.BioMed research international · 2022Pooled it
- Recurrence rate, time to recurrence, and associated factors after primary pterygium excision with conjunctival-limbal autograft: a prospective cohort study.BMC ophthalmology · 2026Article
- The evaluation of hemogram-related systemic inflammatory markers in pterygium recurrence.BMC ophthalmology · 2026Article
- The Potential Role of Vitamin D in the Pterygium Pathophysiology-A Possible New Therapeutic Perspective and Narrative Review.Journal of clinical medicine · 2025Review
- Genetic evidence implicating circulating lipids and lipid drug targets in pterygium.Computational and structural biotechnology journal · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare parameters of systemic inflammation and serum lipid levels in patients with pterygium versus healthy individuals.
methodsThirty-five patients with pterygium and 30 healthy individuals were enrolled as two respective groups in a retrospective study. The participants' complete blood count (CBC) parameters and levels of serum total cholesterol, low-density lipoprotein, high-density lipoprotein (HDL), and triglycerides (TG) were obtained from digital records and compared. Their neutrophil/lymphocyte, platelet/lymphocyte, and monocyte/HDL ratios were calculated and compared as well. As secondary outcomes, longitudinal length (LL), basal length (BL), and total area (TA) of pterygium among the patients were quantitatively measured by using ImageJ software. Correlations between serum parameters and pterygium measurements were analyzed.
resultsAlthough between-group differences in CBC parameters and the ratios were not statistically significant, HDL levels were significantly lower (p = 0.014) and TG levels significantly higher (p = 0.031) among patients with pterygium than among the controls. A positive correlation was detected between the patient's age and the pterygium's BL (p = 0.002, r = 0.516), LL (p = 0.00, r = 0.547), and TA (p = 0.00, r = 0.515). Neutrophil levels negatively correlated with LL (p = 0.025, β = - 0.308) and TA (p = 0.002, β = - 0.420).
conclusionLocal instead of systemic inflammation should be considered in the management of pterygium. Besides, decreased HDL levels may indicate systemic oxidative stress in patients with the condition.
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