Evidence map›Paper›PMID 32418992›Full record

ArticleBritish journal of cancer2020

Enrichment of the tumour immune microenvironment in patients with desmoplastic colorectal liver metastasis.

Diederik J Höppener, Pieter M H Nierop, Joost Hof, Kostandinos Sideras, Guoying Zhou, Lydia Visser, Annette S H Gouw, Koert P de Jong, Dave Sprengers, Jaap Kwekkeboom and 3 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07564908 (Correlation and Heterogeneity of the Immune Microenvironment and Histopathological Growth Patterns in Resectable Colorectal Cancer Liver Metastases), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07564908 active not recruitingnot on this map

Correlation and Heterogeneity of the Immune Microenvironment and Histopathological Growth Patterns in Resectable Colorectal Cancer Liver Metastases

TypeobservationalSponsorMeng QiuRan2018 to 2030Enrolled64ConditionsColorectal NeoplasmsArmsFormalin-fixed, paraffin-embedded (FFPE) sections of colorectal cancer liver metastases were stained with hematoxylin and eosin (H&E) and Multiplex immunohistochemistry (mIHC) staining.
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Diederik J HöppenerDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Pieter M H NieropDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Joost HofDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Kostandinos SiderasDepartment of Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Guoying ZhouDepartment of Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Lydia VisserDepartment of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Annette S H GouwDepartment of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Koert P de JongDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Dave SprengersDepartment of Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Jaap KwekkeboomDepartment of Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Peter B VermeulenTranslational Cancer Research Unit (GZA Hospitals and University of Antwerp), Antwerp, Belgium.
Dirk J GrünhagenDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Cornelis VerhoefDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. c.verhoef@erasmusmc.nl.
Erasmus MC Cancer Institute · NLErasmus University Rotterdam · NLUniversity Medical Center Groningen · NLUniversity of Antwerp · BEUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with resected colorectal liver metastasis (CRLM) who display only the desmoplastic histopathological growth pattern (dHGP) exhibit superior survival compared to patients with any non-desmoplastic growth (non-dHGP). The aim of this study was to compare the tumour microenvironment between dHGP and non-dHGP.

methodsThe tumour microenvironment was investigated in three cohorts of chemo-naive patients surgically treated for CRLM. In cohort A semi-quantitative immunohistochemistry was performed, in cohort B intratumoural and peritumoural T cells were counted using immunohistochemistry and digital image analysis, and in cohort C the relative proportions of individual T cell subsets were determined by flow cytometry.

resultsOne hundred and seventeen, 34, and 79 patients were included in cohorts A, B, and C, with dHGP being observed in 27%, 29%, and 15% of patients, respectively. Cohorts A and B independently demonstrated peritumoural and intratumoural enrichment of cytotoxic CD8+ T cells in dHGP, as well as a higher CD8+/CD4+ ratio (cohort A). Flow cytometric analysis of fresh tumour tissues in cohort C confirmed these results; dHGP was associated with higher CD8+ and lower CD4+ T cell subsets, resulting in a higher CD8+/CD4+ ratio.

conclusionThe tumour microenvironment of patients with dHGP is characterised by an increased and distinctly cytotoxic immune infiltrate, providing a potential explanation for their superior survival.

Indexed as

AgedBiomarkers, TumorCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell ProliferationColorectal NeoplasmsFemaleHumansImmunohistochemistryLiver NeoplasmsLymphocytes, Tumor-InfiltratingMaleMiddle AgedT-Lymphocyte SubsetsTumor MicroenvironmentBiomarkers, Tumor

Identifiers

PMID32418992
PMCPMC7374625
OpenAlexW3024659015

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.