Evidence map›Paper›PMID 32418955›Full record

ArticleInternal medicine (Tokyo, Japan)2020

An Autopsy Case of Mixed Connective Tissue Disease Complicated by Thrombotic Thrombocytopenic Purpura.

Makiko Yashiro Furuya, Hiroshi Watanabe, Shuzo Sato, Yuya Fujita, Jumpei Tenmoku, Naoki Matsuoka, Tomoyuki Asano, Eiji Suzuki, Hiroko Kobayashi, Kiyoshi Migita

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Makiko Yashiro FuruyaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Hiroshi WatanabeDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Shuzo SatoDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Yuya FujitaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Jumpei TenmokuDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Naoki MatsuokaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Tomoyuki AsanoDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Eiji SuzukiDivision of Rheumatology, Ohta-Nishinouchi Hospital, Japan.
Hiroko KobayashiDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Kiyoshi MigitaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Fukushima Medical University · JPOhta Nishinouchi Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a patient with mixed connective tissue disease (MCTD) who had been stable for years but suddenly developed thrombotic thrombocytopenic purpura (TTP). The patient showed a clinical pentad of signs of TTP, low activity of ADAMTS13, and positivity of anti-ADAMTS13 antibodies. She did not respond to plasma exchange or steroid therapy and died five days after admission. An autopsy revealed microthrombi in the brain, heart, kidney, adrenal glands, esophageal submucosa, and bone marrow as well as diffuse alveolar hemorrhaging. Physicians should bear in mind that TTP can occur in MCTD patients regardless of disease activity.

Indexed as

ADAMTS13 ProteinAdrenal Cortex HormonesAutoantibodiesAutopsyFatal OutcomeFemaleHumansMaleMixed Connective Tissue DiseasePlasma ExchangePurpura, Thrombotic ThrombocytopenicADAMTS13 ProteinADAMTS13 protein, humanAdrenal Cortex HormonesAutoantibodiesa disintegrin-like metalloproteinase with thrombospondin type 1 motifautopsymember 13 (ADAMTS13)mixed connective tissue disease (MCTD)thrombotic thrombocytopenic purpura (TTP)

Identifiers

PMID32418955
PMCPMC7303452
OpenAlexW3025933603

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.