Evidence map›Paper›PMID 32418948›Full record

ArticleJournal of atherosclerosis and thrombosis2021

Renal Function-Dependent Associations of Statins with Outcomes of Ischemic Stroke.

Shin-Joe Yeh, Sung-Chun Tang, Li-Kai Tsai, Chih-Hung Chen, Shih-Pin Hsu, Yu Sun, Li-Ming Lien, Cheng-Yu Wei, Ta-Chang Lai, Po-Lin Chen and 10 more

Abstract read
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In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Shin-Joe YehStroke Center and Department of Neurology, National Taiwan University Hospital.
Sung-Chun TangStroke Center and Department of Neurology, National Taiwan University Hospital.
Li-Kai TsaiStroke Center and Department of Neurology, National Taiwan University Hospital.
Chih-Hung ChenDepartment of Neurology, National Cheng Kung University Hospital.
Shih-Pin HsuDepartment of Neurology, E-Da Hospital.
Yu SunDepartment of Neurology, En Chu Kong Hospital.
Li-Ming LienDepartment of Neurology, Shin Kong Wu-Ho-Su Memorial Hospital.
Cheng-Yu WeiDepartment of Neurology, Show Chwan Memorial Hospital.
Ta-Chang LaiDepartment of Neurology, Cheng Hsin General Hospital.
Po-Lin ChenDepartment of Neurology, Taichung Veterans General Hospital.
Chien-Chung ChenDepartment of Neurology, St. Martin De Porres Hospital.
Pai-Hao HuangDepartment of Neurology, Cathay General Hospital.
Ching-Huang LinDepartment of Neurology, Kaohsiung Veterans General Hospital.
Chung-Hsiang LiuDepartment of Neurology, China Medical University Hospital.
Huey-Juan LinDepartment of Neurology, Chi Mei Medical Center.
Chaur-Jong HuDepartment of Neurology, Taipei Medical University-Shuang Ho Hospital.
Cheng-Li LinGraduate Institute of Biomedical Sciences, China Medical University and Hospital.
Jiann-Shing JengStroke Center and Department of Neurology, National Taiwan University Hospital.
Chung Y HsuGraduate Institute of Clinical Medical Science, China Medical University and Hospital.
and Taiwan Stroke Registry Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimChronic kidney disease (CKD) is associated with unfavorable outcomes in patients with ischemic stroke. One major metabolic derangement of CKD is dyslipidemia, which can be managed by statins. This study aimed to investigate whether the association of statins with post-stroke outcomes would be affected by renal function.

methodsWe evaluated the association of statin therapy at discharge with 3-month outcomes according to the estimated glomerular filtration rate (eGFR) of 50,092 patients with acute ischemic stroke from the Taiwan Stroke Registry from August 2006 to May 2016. The outcomes were mortality, functional outcome as modified Rankin Scale (mRS), and recurrent ischemic stroke at 3 months after index stroke.

resultsStatin therapy at discharge was associated with lower risks of mortality (adjusted hazard ratio [aHR], 0.41; 95% confidence interval [CI], 0.34 to 0.50) and unfavorable functional outcomes (mRS 3-5; aHR, 0.80; 95% CI, 0.76 to 0.84) in ischemic stroke patients. After stratification by eGFR, the lower risk of mortality associated with statins was limited to patients with an eGFR above 15 mL/min/1.73 m

conclusionsIn patients with acute ischemic stroke, the associations of statins with mortality and functional outcomes was dependent on eGFR.

Indexed as

DyslipidemiasGlomerular Filtration RateIschemic StrokeRenal Insufficiency, ChronicAgedComorbidityFemaleFunctional StatusHumansHydroxymethylglutaryl-CoA Reductase InhibitorsKidney Function TestsMaleMiddle AgedOutcome Assessment, Health CareRegistriesRisk AssessmentHydroxymethylglutaryl-CoA Reductase InhibitorsBrain infarctionDyslipidemiaOutcomeRenal functionStatins

Identifiers

PMID32418948
PMCPMC7957032

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.