Evidence map›Paper›PMID 32418585›Full record

ReviewEndocrinology and metabolism clinics of North America2020

Sex Differences in Adipose Tissue Function.

Kathleen M Gavin, Daniel H Bessesen

Open access · greenAbstract readReview
In one paragraph

Review in Endocrinology and metabolism clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 5 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 5 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Precision or Paradox? AI-Driven Adiposity Imaging in Women With Overweight and Obesity: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Pooled it
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  4. Body mass index and subsequent fracture risk: a meta-analysis to update FRAX.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Pooled it
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  10. Cells · 2026
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kathleen M GavinDivision of Geriatric Medicine, Department of Medicine, Eastern Colorado VA Geriatric, Research, Education, and Clinical Center (GRECC), University of Colorado Anschutz Medical Campus, 12631 East 17th Avenue, Aurora, CO 80045, USA.
Daniel H BessesenDivision of Endocrinology, Metabolism, and Diabetes, Anschutz Health and Wellness Center, University of Colorado, School of Medicine, 12348 East Montview Boulevard, Aurora, CO 80045, USA. Electronic address: DANIEL.BESSESEN@CUANSCHUTZ.EDU.
Geriatric Research Education and Clinical Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Suppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon ReceptorU54AG062319 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2018 to 2026
$13.5M
Sex Hormones Differentially Regulate Production of Distinct Adipocyte PopulationP50HD073063 · NICHD · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2012 to 2017
$5.7M
Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized TrialR01DK111622 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CATENACCI, VICTORIA A · 2017 to 2021
$4.4M
Adaptive responses to overfeeding and weight regain in reduced obese individualsR01DK114272 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BESSESEN, DANIEL HOLLAND · 2018 to 2022
$2.5M
Sex differences in adipogenic potential of adipose tissue myeloid cells in humansK01DK109053 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GAVIN, KATHLEEN MARIE · 2016 to 2020
$724k
NIA NIH HHS U54 AG062319NICHD NIH HHS P50 HD073063NIDDK NIH HHS K01 DK109053NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK111622NIDDK NIH HHS R01 DK114272
6 · The paper itself

Abstract

Regional adipose tissue distribution differs between men and women. Differences in the accumulation of adipose tissue as well as the regulation of secretion of a number of products from adipose tissue are under the control of sex steroids, which act through a wide variety of mechanisms, both direct and indirect, to tailor metabolism to the unique needs of each sex. A fuller understanding of sex-based differences in adipose tissue function may help with tailored strategies for disease prevention and treatment and provide insights into fundamental differences in the processes that regulate nutrient homeostasis and body weight.

Indexed as

Sex CharacteristicsAdipogenesisAdiponectinAdipose TissueAdultEstrogensFemaleHumansLeptinLipolysisMaleTestosteroneAdiponectinEstrogensLeptinTestosteroneEstrogenHormone actionHormone replacement therapyRegional adipositySex differencesTestosterone

Identifiers

PMID32418585
PMCPMC7921847
OpenAlexW3017383931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.