Evidence map›Paper›PMID 32418432›Full record

ArticleOrganic letters2020

Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore.

David A Brumley, Sarath P Gunasekera, Qi-Yin Chen, Valerie J Paul, Hendrik Luesch

Open access · greenAbstract read
In one paragraph

Article in Organic letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David A Brumley
Sarath P GunasekeraSmithsonian Marine Station, 701 Seaway Drive, Ft. Pierce, Florida 34949, United States.
Qi-Yin Chen
Valerie J PaulSmithsonian Marine Station, 701 Seaway Drive, Ft. Pierce, Florida 34949, United States.ORCID 0000-0002-4691-1569
University of Florida · USSmithsonian Marine Station · US

Funding

Novel Targeted Anticancer Agents from Marine CyanobacteriaR01CA172310 · NCI · UNIVERSITY OF FLORIDA · PI HENDRIK LUESCH · 2013 to 2026
$5.8M
NCI NIH HHS R01 CA172310
6 · The paper itself

Abstract

New modified depsipeptides and geometric isomers, termed anaenamides A (

Indexed as

Drug DiscoveryAntineoplastic AgentsCell ProliferationCell SurvivalCyanobacteriaDose-Response Relationship, DrugDrug Screening Assays, AntitumorHalogenationHCT116 CellsHumansMolecular StructureStructure-Activity RelationshipAntineoplastic Agents

Identifiers

PMID32418432
PMCPMC7395482
OpenAlexW3025236321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.