Evidence map›Paper›PMID 32418425›Full record

ArticleJournal of proteome research2020

Metabolite Profiling Reveals Predictive Biomarkers and the Absence of β-Methyl Amino-l-alanine in Plasma from Individuals Diagnosed with Amyotrophic Lateral Sclerosis.

Michael S Bereman, Kaylie I Kirkwood, Tharani Sabaretnam, Sarah Furlong, Dominic B Rowe, Gilles J Guillemin, Allyson L Mellinger, David C Muddiman

Abstract read
In one paragraph

Article in Journal of proteome research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Gut Symptoms, Gut Dysbiosis and Gut-Derived Toxins in ALS.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. ILBJournal of personalized medicine · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael S BeremanDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0002-2722-064X
Kaylie I KirkwoodDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Tharani SabaretnamThe Centre for MND Research Faculty of Medicine, Health and Human Sciences Macquarie University, Sydney, NSW 2109, Australia.
Sarah FurlongThe Centre for MND Research Faculty of Medicine, Health and Human Sciences Macquarie University, Sydney, NSW 2109, Australia.
Dominic B RoweThe Centre for MND Research Faculty of Medicine, Health and Human Sciences Macquarie University, Sydney, NSW 2109, Australia.
Gilles J GuilleminThe Centre for MND Research Faculty of Medicine, Health and Human Sciences Macquarie University, Sydney, NSW 2109, Australia.
Allyson L MellingerDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
David C MuddimanDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0003-2216-499X

Funding

Uncovering new genes and disease modifiers for ALS and related disordersU54NS092091 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Marka Van Blitterswijk · 2014 to 2026
$19.8M
NINDS NIH HHS U54 NS092091
6 · The paper itself

Abstract

By employing chip-based capillary zone electrophoresis coupled to high-resolution mass spectrometry, we profiled the plasma metabolome of 134 patients diagnosed with sporadic amyotrophic lateral sclerosis (ALS) (81 males and 53 females) and 118 individuals deemed healthy (49 males and 69 females). The most significant markers (

Indexed as

Amyotrophic Lateral SclerosisAlanineBiomarkersFemaleHumansMaleMass SpectrometryMetabolomeAlanineBiomarkersamyotrophic lateral sclerosisbiomarkersBMAACZE-MS/MSmetabolitesplasma

Identifiers

PMID32418425
PMCPMC8273918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.