ArticleJournal of biomedical materials research. Part A2021
3D printing of high-strength, porous, elastomeric structures to promote tissue integration of implants.
Article in Journal of biomedical materials research. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparing functional outcomes between 3D printed acetabular cups and traditional prosthetic implants in hip arthroplasty: a systematic review and meta analysis.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Three-Dimensional Printing Parameter Assessment of Elastomers for Tendon Graft Applications.Biomimetics (Basel, Switzerland) · 2025Article
- Compliant buffer layer achieves native-like cartilage stress in talar prosthesis: a finite element analysis study.Journal of orthopaedic surgery and research · 2025Article
- Freeze drying and Lugol staining of human menisci reveal circumferential fibre volumes to guide meniscus implant design and virtual simulation.Scientific reports · 2025Article
- Dumbbell-shaped hydrogel plug for annulus fibrosus repair: From material design to in vivo validation.Journal of orthopaedic translation · 2025Article
- Bioactive Composite Membranes: Preclinical Analysis of PBAT/BAGNb Composition to Enhance the Quality of Guided Bone Regeneration.ACS applied materials & interfaces · 2025Article
- Article
- 3D-Printed Personalized Lattice Implant as an Innovative Strategy to Reconstruct Geographic Defects in Load-Bearing Bones.Orthopaedic surgery · 2024Article
- Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives.Gels (Basel, Switzerland) · 2024Review
- 4D printing of biocompatible, hierarchically porous shape memory polymeric structures.Biomaterials advances · 2023Article
- Novel Fabrication of 3-D Cell Laden Micro-Patterned Porous Structure on Cell Growth and Proliferation by Layered Manufacturing.Bioengineering (Basel, Switzerland) · 2023Article
- Finite element analysis of posterior acetabular column plate and posterior acetabular wall prostheses in treating posterior acetabular fractures.Journal of orthopaedic surgery and research · 2023Article
- The triply periodic minimal surface-based 3D printed engineering scaffold for meniscus function reconstruction.Biomaterials research · 2022Article
- Outcomes of Surgical Reconstruction Using Custom 3D-Printed Porous Titanium Implants for Critical-Sized Bone Defects of the Foot and Ankle.Foot & ankle international · 2022Article
- Article
- Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicine.Cytoskeleton (Hoboken, N.J.) · 2021Review
- Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates.Bioengineering (Basel, Switzerland) · 2021Review
- Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications.Frontiers in cell and developmental biology · 2021Review
- Meniscus regeneration by 3D printing technologies: Current advances and future perspectives.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Despite advances in biomaterials research, there is no ideal device for replacing weight-bearing soft tissues like menisci or intervertebral discs due to poor integration with tissues and mechanical property mismatch. Designing an implant with a soft and porous tissue-contacting structure using a material conducive to cell attachment and growth could potentially address these limitations. Polycarbonate urethane (PCU) is a soft and tough biocompatible material that can be 3D printed into porous structures with controlled pore sizes. Porous biomaterials of appropriate chemistries can support cell proliferation and tissue ingrowth, but their optimal design parameters remain unclear. To investigate this, porous PCU structures were 3D-printed in a crosshatch pattern with a range of in-plane pore sizes (0 to 800 μm) forming fully interconnected porous networks. Printed porous structures had ultimate tensile strengths ranging from 1.9 to 11.6 MPa, strains to failure ranging from 300 to 486%, Young's moduli ranging from 0.85 to 12.42 MPa, and porosity ranging from 13 to 71%. These porous networks can be loaded with hydrogels, such as collagen gels, to provide additional biological support for cells. Bare PCU structures and collagen-hydrogel-filled porous PCU support robust NIH/3T3 fibroblast cell line proliferation over 14 days for all pore sizes. Results highlight PCU's potential in the development of tissue-integrating medical implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.