Evidence map›Paper›PMID 32418288›Full record

ArticleAnnals of neurology2020

Steroid-Responsive Encephalitis in Coronavirus Disease 2019.

Andrea Pilotto, Silvia Odolini, Stefano Masciocchi, Agnese Comelli, Irene Volonghi, Stefano Gazzina, Sara Nocivelli, Alessandro Pezzini, Emanuele Focà, Arnaldo Caruso and 8 more

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Annals of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 19 pooled it
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 19 syntheses or guidelines pooled it, 298 citations in OpenAlex.

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  5. Autoimmune encephalitis associated with COVID-19: A systematic review.Multiple sclerosis and related disorders · 2022
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  10. COVID-19 associated brain/spinal cord lesions and leptomeningeal enhancement: A meta-analysis of the relationship to CSF SARS-CoV-2.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
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  13. COVID-19, de novo seizures, and epilepsy: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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  16. Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Andrea PilottoNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.ORCID 0000-0003-2029-6606
Silvia OdoliniUniversity Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.
Stefano MasciocchiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Agnese ComelliUniversity Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.
Irene VolonghiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Stefano GazzinaNeurophysiology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.
Sara NocivelliNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Alessandro PezziniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Emanuele FocàUniversity Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.ORCID 0000-0003-4395-5379
Arnaldo CarusoMicrobiology Unit, Department of Molecular and Translational Medicine, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.
Matilde LeonardiNeurology, Public Health, Disability Unit - IRCCS Neurology Institute Besta, Milan, Italy.
Maria P PasoliniNeurophysiology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.
Roberto GasparottiNeuroradiology Unit, Department of Molecular and Translational Medicine, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.ORCID 0000-0002-2591-2415
Francesco CastelliUniversity Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID 0000-0003-3930-4354
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.ORCID 0000-0002-0119-3639
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Brescia · ITSahlgrenska University Hospital · SEFondazione Europea Ricerca Biomedica · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been described in patients with severe respiratory distress. Here, we described the case of a 60-year-old patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection but only mild respiratory abnormalities who developed an akinetic mutism attributable to encephalitis. Magnetic resonance imaging was negative, whereas electroencephalography showed generalized theta slowing. Cerebrospinal fluid analyses during the acute stage were negative for SARS-CoV-2, positive for pleocytosis and hyperproteinorrachia, and showed increased interleukin-8 and tumor necrosis factor-α concentrations. Other infectious or autoimmune disorders were excluded. A progressive clinical improvement along with a reduction of cerebrospinal fluid parameters was observed after high-dose steroid treatment, thus arguing for an inflammatory-mediated brain involvement related to COVID-19. ANN NEUROL 2020;88:423-427.

Indexed as

Akinetic MutismAntiviral Agentsbeta 2-MicroglobulinBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDrug CombinationsElectroencephalographyEncephalitisGlucocorticoidsHumansHydroxychloroquineInterleukin-6Interleukin-8LopinavirAntiviral Agentsbeta 2-MicroglobulinDrug CombinationsGlucocorticoidsHydroxychloroquineInterleukin-6Interleukin-8Lopinavirlopinavir-ritonavir drug combinationMethylprednisoloneRitonavirTumor Necrosis Factor-alpha

Identifiers

PMID32418288
PMCPMC7276848
OpenAlexW3025998153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.