ArticleJournal of veterinary internal medicine2020
Brain proton magnetic resonance spectroscopy findings in a Beagle dog with genetically confirmed Lafora disease.
Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Article
- MRI characteristics due to gene mutations in a Chinese pedigree with Lafora disease.Molecular genetics & genomic medicine · 2023Article
- Lafora Disease and Alpha-Synucleinopathy in Two Adult Free-Ranging Moose (Animals : an open access journal from MDPI · 2022Article
- Single-Voxel Proton Magnetic Resonance Spectroscopy of the Thalamus in Idiopathic Epileptic Dogs and in Healthy Control Dogs.Frontiers in veterinary science · 2022Article
- A retrospective case series of clinical signs in 28 Beagles with Lafora disease.Journal of veterinary internal medicine · 2021Article
- Structural and Functional Brain Abnormalities in Mouse Models of Lafora Disease.International journal of molecular sciences · 2020Article
- Brain proton magnetic resonance spectroscopy findings in a Beagle dog with genetically confirmed Lafora disease.Journal of veterinary internal medicine · 2020Article
- Single-Voxel Proton Magnetic Resonance Spectroscopy Findings at 3 Tesla in a Dog With Gliomatosis Cerebri.Journal of veterinary internal medicineArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical atrophy has been identified using magnetic resonance imaging (MRI) in humans and dogs with Lafora disease (LD). In humans, proton magnetic resonance spectroscopy (1HMRS) of the brain indicates decreased N-acetyl-aspartate (NAA) relative to other brain metabolites. Brain 1HMRS findings in dogs with LD are lacking. A 6-year-old female Beagle was presented with a history of a single generalized tonic-clonic seizure and episodic reflex myoclonus. Clinical, hematological, and neurological examination findings and 3-Tesla MRI of the brain were unremarkable. Brain 1HMRS with voxel positioning in the thalamus was performed in the affected Beagle. It identified decreased amounts of NAA, glutamate-glutamine complex, and increased total choline and phosphoethanolamine relative to water and total creatine compared with the reference range in healthy control Beagles. A subsequent genetic test confirmed LD. Abnormalities in 1HMRS despite lack of changes with conventional MRI were identified in a dog with LD.
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Registered trials
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