Evidence map›Paper›PMID 32418251›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2021

Faecal calprotectin and gut microbiota do not predict enteropathy in very preterm infants.

Florence Campeotto, Caroline Elie, Clotilde Rousseau, Agnès Giuseppi, Taymme Hachem, Ponny Gobalakichenane, Mathilde Le Touzey, Marie de Stefano, Marie-José Butel, Nathalie Kapel

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02010268 (Evaluation of a Clinico-biological Predictive Score of Enterocolitis and Enteropathy of the Preterm Neonates. Usefulness of the Rapid Assay of the Faecal Calprotectin.), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02010268 nacompletednot on this map

Evaluation of a Clinico-biological Predictive Score of Enterocolitis and Enteropathy of the Preterm Neonates. Usefulness of the Rapid Assay of the Faecal Calprotectin.

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2013 to 2015Enrolled122ConditionsEnteropathy, Necrotizing EnterocolitisArmsCollection of stool samples
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Florence CampeottoDepartment of Pediatric Gastroenterology, Necker-Enfants Malades Hospital, AP-HP, Paris, France.
Caroline ElieClinical Research Unit, Clinical Investigation Center, Necker-Enfants Malades Hospital, AP-HP, Paris, France.
Clotilde RousseauFaculty of Pharmacy, INSERM, U1139, Paris, France.
Agnès GiuseppiNeonatology Department, Necker-Enfants Malades Hospital, AP-HP, Paris, France.
Taymme HachemNeonatology Department, Necker-Enfants Malades Hospital, AP-HP, Paris, France.
Ponny GobalakichenaneNeonatology Department, Armand Trousseau Hospital, AP-HP, Paris, France.
Mathilde Le TouzeyNeonatology Department, Poissy-Saint Germain Intercommunal Hospital Center, Poissy, France.
Marie de StefanoFaculty of Pharmacy, INSERM, U1139, Paris, France.
Marie-José ButelFaculty of Pharmacy, INSERM, U1139, Paris, France.ORCID 0000-0003-4249-2130
Nathalie KapelFaculty of Pharmacy, INSERM, U1139, Paris, France.
Délégation Paris 5 · FRHôpital Necker-Enfants Malades · FRCentre Hospitalier Intercommunal de Poissy · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimVery preterm birth is associated with a high risk of enteropathies. Diagnosis is challenging, especially in mild forms, leading to unnecessary periods of cessation of enteral feeding. This study aimed at establishing a prognosis score of enteropathy combining clinical parameters and faecal calprotectin concentration.

methodsThis prospective multicentric study included preterm neonates born at a gestational age of 33 weeks or less. Stools were collected weekly until hospital discharge, and daily in case of digestive events for calprotectin measurement (ELISA and immunochromatography) and microbiota analyses (16S rRNA gene sequencing).

resultsAmong the 121 neonates included, 21 experienced at least one episode of enteropathy, mainly mild forms. By ELISA testing, median faecal calprotectin was 88 (8-798) µg/g faeces. No statistically significant association was found between the outset of enteropathy and maternal and neonatal characteristics, and calprotectin levels. The agreement between ELISA and immunochromatography assay was moderate (intra-class correlation coefficient 0.58, 95%CI [0.47-0.66]). Comparison of species diversity and relative bacterial abundance profiles between infants with or without enteropathy revealed no specific alterations associated with enteropathy.

conclusionThe study failed to propose a prognostic score of enteropathy, probably due the large inter- and intra-individual variability of faecal calprotectin in very preterm neonates.

Indexed as

Gastrointestinal MicrobiomePremature BirthFecesFemaleHumansInfantInfant, NewbornInfant, PrematureLeukocyte L1 Antigen ComplexPregnancyProspective StudiesRNA, Ribosomal, 16SLeukocyte L1 Antigen ComplexRNA, Ribosomal, 16Senteropathyfaecal calprotectingut microbiotanecrotising enterocolitispreterm neonates

Identifiers

PMID32418251
PMCPMC7818215
OpenAlexW3025259325

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.