Evidence map›Paper›PMID 32418250›Full record

ArticleAnnals of neurology2020

Quantitative Separation of Tremor and Ataxia in Essential Tremor.

Agostina Casamento-Moran, Basma Yacoubi, Bradley J Wilkes, Christopher W Hess, Kelly D Foote, Michael S Okun, Aparna Wagle Shukla, David E Vaillancourt, Evangelos A Christou

Open access · greenAbstract read
In one paragraph

Article in Annals of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Force control deficits in rapid eye movement behavior disorder and Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Quantifying Tremor in Essential Tremor Using Inertial Sensors-Validation of an Algorithm.IEEE journal of translational engineering in health and medicine · 2021
    Article
  13. Dysmetria and Errors in Predictions: The Role of Internal Forward Model.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Agostina Casamento-MoranDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Basma YacoubiDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Bradley J WilkesDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Christopher W HessDepartment of Neurology, Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Kelly D FooteDepartment of Neurology, Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Michael S OkunDepartment of Neurology, Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Aparna Wagle ShuklaDepartment of Neurology, Fixel Institute for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
David E VaillancourtDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Evangelos A ChristouDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-4890-4706
University of Florida · US

Funding

Role of the Cortex and Cerebellum in Visually-Guided Motor BehaviorR01NS058487 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JAFFEE, MICHAEL S., VAILLANCOURT, DAVID E · 2008 to 2025
$6.1M
Motor Control Deficits Following Transient Ischemic AttackR21NS096258 · NINDS · UNIVERSITY OF FLORIDA · PI CHRISTOU, EVANGELOS A, LODHA, NEHA · 2016 to 2017
$418k
National Institute of Health (NIH) R01NS058487National Institute of Health (NIH) R21NS096258NINDS NIH HHS R01 NS058487NINDS NIH HHS R21 NS096258
6 · The paper itself

Abstract

objectiveThis study addresses an important problem in neurology, distinguishing tremor and ataxia using quantitative methods. Specifically, we aimed to quantitatively separate dysmetria, a cardinal sign of ataxia, from tremor in essential tremor (ET).

methodsIn Experiment 1, we compared 19 participants diagnosed with ET undergoing thalamic deep brain stimulation (DBS; ET

resultsThree findings suggest that we can quantify dysmetria independently of tremor in ET. First, ET

interpretationWe demonstrate that dysmetria can be quantified independently of tremor using fast, reverse-at-target goal-directed movements. These results have important implications for the understanding of ET and other cerebellar and tremor disorders. Future research should examine the neurophysiological mechanisms underlying each symptom and characterize their independent contribution to disability. ANN NEUROL 2020;88:375-387.

Indexed as

AgedCerebellar AtaxiaDeep Brain StimulationDiagnosis, DifferentialEssential TremorFemaleHumansMaleMiddle AgedPostureTremor

Identifiers

PMID32418250
PMCPMC8324074
OpenAlexW3025773437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.