Evidence map›Paper›PMID 32418154›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2020

Update of the recommendations for the determination of biomarkers in colorectal carcinoma: National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology.

P García-Alfonso, R García-Carbonero, J García-Foncillas, P Pérez-Segura, R Salazar, R Vera, S Ramón Y Cajal, J Hernández-Losa, S Landolfi, E Musulén and 2 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. SEOM-GETTHI clinical guideline for the practical management of molecular platforms (2021).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Guideline
  3. SEOM‑GETTHI clinical guideline for the practical management of molecular platforms (update 2026).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. SEOM-GEMCAD-TTD clinical guidelines for the systemic treatment of metastatic colorectal cancer (2022).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

P García-AlfonsoDepartament of Medical Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain. pgarcaalfonso@gmail.com.ORCID http://orcid.org/0000-0002-4373-9978
R García-CarboneroDepartament of Medical Oncology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), UCM, CNIO, CIBERONC, Madrid, Spain.
J García-FoncillasDepartament of Medical Oncology, Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.
P Pérez-SeguraDepartament of Medical Oncology, Hospital Clínico Universitario San Carlos, CIBERONC, Madrid, Spain.
R SalazarDepartament of Medical Oncology, ICO L'Hospitalet, Oncobell Program (IDIBELL), CIBERONC, Hospitalet de Llobregat, Spain.
R VeraDepartament of Medical Oncology, Complejo Hospitalario de Navarra; Navarrabiomed, IDISNA, Pamplona, Spain.
S Ramón Y CajalDepartment of Pathology, Hospital Universitario Vall D'Hebron, CIBERONC, Barcelona, Spain.
J Hernández-LosaDepartment of Pathology, Hospital Universitario Vall D'Hebron, CIBERONC, Barcelona, Spain.
S LandolfiDepartment of Pathology, Hospital Universitario Vall D'Hebron, CIBERONC, Barcelona, Spain.
E MusulénDepartment of Pathology, Hospital Universitari General de Catalunya, Grupo Quirónsalud, Sant Cugat del Vallès, Spain.
M CuatrecasasDepartment of Pathology, Hospital Clinic, CIBERehd, Barcelona, Spain.
S NavarroDepartment of Pathology, University of Valencia, Hospital Clínico Universitario de Valencia, CIBERONC, Valencia, Spain.
Centro de Investigación Biomédica en Red de Cáncer · ESComplejo Hospitalario de Navarra · ESHospital Clínic de Barcelona · ESHospital Clínico San Carlos · ESHospital General de Catalunya · ESHospital General Universitario Gregorio Marañón · ESHospital Universitario 12 De Octubre · ESHospital Universitario Fundación Jiménez Díaz · ESInstitut d'Investigació Biomédica de Bellvitge · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this update of the consensus of the Spanish Society of Medical Oncology (Sociedad Española de Oncología Médica-SEOM) and the Spanish Society of Pathology (Sociedad Española de Anatomía Patológica-SEAP), advances in the analysis of biomarkers in advanced colorectal cancer (CRC) as well as susceptibility markers of hereditary CRC and molecular biomarkers of localized CRC are reviewed. Recently published information on the essential determination of KRAS, NRAS and BRAF mutations and the convenience of determining the amplification of human epidermal growth factor receptor 2 (HER2), the expression of proteins in the DNA repair pathway and the study of NTRK fusions are also evaluated. From the pathological point of view, the importance of analysing the tumour budding and poorly differentiated clusters, and its prognostic value in CRC is reviewed, as well as the impact of molecular lymph node analysis on lymph node staging in CRC. The incorporation of pan-genomic technologies, such as next-generation sequencing (NGS) and liquid biopsy in the clinical management of patients with CRC is also outlined. All these aspects are developed in this guide, which, like the previous one, will remain open to any necessary revision in the future.

Indexed as

Biomarkers, TumorColorectal NeoplasmsHigh-Throughput Nucleotide SequencingHumansLiquid BiopsyMedical OncologyMutationPathologySocieties, MedicalSpainBiomarkers, TumorDiagnosisGastrointestinalGenetic prognosisNeoplastic diseaseTumour

Identifiers

PMID32418154
PMCPMC7505870
OpenAlexW3024300932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.