Evidence map›Paper›PMID 32418121›Full record

ArticleTheory in biosciences = Theorie in den Biowissenschaften2020

On the problem of biological form.

Marta Linde-Medina

Abstract read
PubMed Publisher
In one paragraph

Article in Theory in biosciences = Theorie in den Biowissenschaften, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Marta Linde-MedinaLaboratory of Bioengineering and Morphogenesis, Department of Biomechanical Engineering, KU Leuven, Celestijnenlaan 200F, 3001, Louvain, Belgium. linde.m@outlook.com.ORCID http://orcid.org/0000-0002-8141-6301

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryonic development, which inspired the first theories of biological form, was eventually excluded from the conceptual framework of the Modern Synthesis as irrelevant. A major question during the last decades has centred on understanding whether new advances in developmental biology are compatible with the standard view or whether they compel a new theory. Here, I argue that the answer to this question depends on which concept of morphogenesis is held. Morphogenesis can be conceived as (1) a chemically driven or (2) a mechanically driven process. According to the first option, genetic regulatory networks drive morphogenesis. According to the second, morphogenesis results from an invariant tendency of embryonic tissues to restore changes in mechanical stress. While chemically driven morphogenesis allows an extension of the standard view, mechanically driven morphogenesis would deeply transform it. Which of these hypotheses has wider explanatory power is unknown. At present, the problem of biological form remains unsolved.

Indexed as

Body PatterningEmbryonic DevelopmentGene Regulatory NetworksAnimalsCell DifferentiationDevelopmental BiologyDrosophilaEpigenesis, GeneticFeedbackHumansMiceModels, BiologicalModels, GeneticMorphogenesisStress, MechanicalEpigenesisGenetic programMorphogenesisPreformationismSelf-organisationTissue patterning

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.