Evidence map›Paper›PMID 32418064›Full record

Trial reportReviews in endocrine & metabolic disorders2020

Acute assessment of subjective appetite and implicated hormones after a hypnosis-induced hallucinated meal: a randomized cross-over pilot trial.

Iolanda Cioffi, Roberto Gambino, Rosalba Rosato, Bice Properzi, Giuseppe Regaldo, Valentina Ponzo, Marianna Pellegrini, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo and 1 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Reviews in endocrine & metabolic disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03934580 (Postprandial Effects of a Hallucinatory Meal on Appetite Regulation), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03934580 nacompletednot on this map

Postprandial Effects of a Hallucinatory Meal on Appetite Regulation: a Randomized Cross-over Pilot Trial

TypeinterventionalSponsorUniversity of Turin, ItalyRan2017 to 2019Enrolled8ConditionsChange in Subjective Appetite Score (VAS)Armshallucinated meal, Real meal
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Iolanda CioffiDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Turin, Italy.
Roberto GambinoDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Turin, Italy.
Rosalba RosatoDepartment of Psychology, University of Turin, Turin, Italy.
Bice ProperziUnit of Internal Medicine, Hospital of Turin, Città della Salute e della Scienza, Turin, Italy.
Giuseppe RegaldoObstetric Department, Hospital of Ciriè, Turin, Italy.
Valentina PonzoDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Turin, Italy.
Marianna PellegriniDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Turin, Italy.
Franco ContaldoDepartment of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy.
Fabrizio PasanisiDepartment of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy.
Ezio GhigoDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Turin, Italy.
Simona BoDepartment of Medical Sciences, University of Turin, c.so AM Dogliotti 14, 10126, Turin, Italy. simona.bo@unito.it.ORCID http://orcid.org/0000-0001-6862-8628
University of Turin · ITFederico II University Hospital · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITDepartment of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of hypnosis can generate hallucinatory phenomena, which ranged from vivid/auditory imagery to fully developed "hallucinations" in selected people. The aim of this pilot trial was investigating the acute effects of a hypnosis-induced hallucinated breakfast (HB) compared to those of a real breakfast (RB) on subjective appetite and appetite-regulating hormones in highly hypnotizable individuals. Eight healthy post-menopausal women were recruited to consume two meals: the HB and the RB in a randomized crossover design. Participants underwent appetite sensations measurements (before meal and each 30-min until 270-min) and blood sample collection (at 0, 20, 60, 90, 180-min). A 3-day food-record was filled after each meal. The adjusted repeated measures ANCOVA did not show any meal×time interactions on subjective appetite postprandially. As expected, significantly higher glucose (p < 0.001), insulin (p < 0.001), and lower free fatty acid (p < 0.001) concentrations were found after the RB, but not following HB. Furthermore, RB significantly increased postprandial levels of glucagon-like-peptide-1 and peptide-YY at 20, 60, 90 and 180-min, whereas acylated-ghrelin and leptin levels did not differ. Postprandial neuropeptide-Y and orexin-A values significantly increased at different time-points after RB, but not following HB, while α-melanocyte-stimulating hormone levels enhanced after HB only. Energy intakes were significantly lower after HB on the test-day only (HB = 1146.6 ± 343.8 vs RB = 1634.7 ± 274.2 kcal/d; p = 0.003). Appetite sensation might be modulated by fully developed meal "hallucination" induced by hypnosis, likely affecting brain-peptides implicated in the appetite regulation. However, further studies are needed to verify these results obtained in a highly selected group of individuals. NCT03934580.

Indexed as

Hypnosisalpha-MSHAppetiteBlood GlucoseBreakfastCross-Over StudiesFemaleGhrelinGlucagon-Like Peptide 1HallucinationsHormonesHumansInsulinItalyLeptinMealsalpha-MSHBlood GlucoseGhrelinGlucagon-Like Peptide 1HormonesInsulinLeptinOrexinsPeptide YYAppetiteHypnosisObesityOrexin, Neuropeptide-Y

Identifiers

PMID32418064
OpenAlexW3024620634

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.