Evidence map›Paper›PMID 32418005›Full record

ArticleInflammopharmacology2020

Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction.

Olumayokun A Olajide, Idowu S Akande, Carlos da Silva Maia Bezerra Filho, Izabela Lepiarz-Raba, Damião Pergentino de Sousa

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Olumayokun A OlajideDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK. o.a.olajide@hud.ac.uk.ORCID http://orcid.org/0000-0002-9254-8334
Idowu S AkandeDepartment of Biochemistry, College of Medicine, University of Lagos, Lagos, Nigeria.
Carlos da Silva Maia Bezerra FilhoLaboratory of Pharmaceutical Chemistry, Federal University of Paraíba, João Pessoa, 58051-085, Brazil.
Izabela Lepiarz-RabaDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK.
Damião Pergentino de SousaLaboratory of Pharmaceutical Chemistry, Federal University of Paraíba, João Pessoa, 58051-085, Brazil.
Universidade Federal da Paraíba · BRUniversity of Huddersfield · GBUniversity of Lagos · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methyl 3,4,5-trimethoxycinnamate (MTC) is a bioactive natural phenylpropanoid. We evaluated anti-inflammatory effects of synthetic MTC in RAW264.7 macrophages and RAW264.7-3T3-L1 adipocytes co-culture. Levels of cytokines and chemokines, as well as NO and PGE

Indexed as

3T3-L1 CellsAdipocytesAMP-Activated Protein Kinase KinasesAnimalsAnti-Inflammatory AgentsAntioxidantsCell LineCytokinesGlucoseInflammationInterleukin-1betaMacrophagesMiceNF-kappa BRAW 264.7 CellsTumor Necrosis Factor-alphaAMP-Activated Protein Kinase KinasesAnti-Inflammatory AgentsAntioxidantsCytokinesGlucoseInterleukin-1betaNF-kappa BTumor Necrosis Factor-alpha3T3-L1 adipocytesAnti-inflammatoryMethyl 3,4,5-trimethoxycinnamateNatural productNF-κBRAW264.7 macrophages

Identifiers

PMID32418005
PMCPMC7524821
OpenAlexW3025248519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.