Evidence map›Paper›PMID 32418003›Full record

ArticleJournal of bioenergetics and biomembranes2020

Synthesis of new N,S-acetal analogs derived from juglone with cytotoxic activity against Trypanossoma cruzi.

Paulo Anastácio Furtado Pacheco, Thais de Menezes Ribeiro, Raíssa Maria Dos Santos Galvão, Eldio Gonçalves Dos Santos, Ana Flávia Martins Faria, Natalia Lidmar von Ranke, Murilo Lamim Bello, Carlos Rangel Rodrigues, Vitor Francisco Ferreira, André Luis Almeida Souza and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of bioenergetics and biomembranes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Paulo Anastácio Furtado PachecoDepartamento de Química Orgânica, Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Outeiro de São João Batista, s/n, Niterói, RJ, 24020-141, Brazil.
Thais de Menezes RibeiroDepartamento de Química Orgânica, Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Outeiro de São João Batista, s/n, Niterói, RJ, 24020-141, Brazil.
Raíssa Maria Dos Santos GalvãoPostgraduate Program in Sciences and Biotechnology, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Eldio Gonçalves Dos SantosPostgraduate Program in Sciences and Biotechnology, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Ana Flávia Martins FariaPostgraduate Program in Sciences and Biotechnology, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil.ORCID 0000-0001-8218-834X
Natalia Lidmar von RankeDepartamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Murilo Lamim BelloDepartamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Carlos Rangel RodriguesDepartamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Vitor Francisco FerreiraDepartamento de Química Orgânica, Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Outeiro de São João Batista, s/n, Niterói, RJ, 24020-141, Brazil.
André Luis Almeida SouzaLaboratory of Biochemistry of Peptides, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Daiana de Jesús HardoimLaboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Katia da Silva CalabreseLaboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Robson Xavier FariaLaboratory of Toxoplasmosis and other Protozoans, Oswaldo Cruz Institute, FIOCRUZ, Avenida Brasil 4365, Carlos Chagas Pavilion, sala 208, Manguinhos, Rio de Janeiro, RJ, CEP 21040-900, Brazil. robson.xavier@gmail.com.
David Rodrigues da RochaDepartamento de Química Orgânica, Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Outeiro de São João Batista, s/n, Niterói, RJ, 24020-141, Brazil. davidrocha@id.uff.br.
Universidade Federal Fluminense · BRFundação Oswaldo Cruz · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 11 new N,S-acetal juglone derivatives were synthesized and evaluated against T. cruzi epimastigote forms. These compounds were obtained in good to moderate yields using a microwave irradiation protocol. Among all compounds, two N,S-acetal analogs, showed significant trypanocidal activity. Notably, one compound 11g exhibited selectivity index 10-fold higher than the reference drug benznidazole for epimastigote. The compound 11h was more effective for amastigote forms. Both prototypes exhibited S.I. higher than the benznidazole description. Thus, both compounds proving to be useful candidate molecules to further studies in infected animals.

Indexed as

AcetalsChagas DiseaseTrypanosoma cruziAcetalsNaphtoquinonesN,S-acetalTrypanosoma cruzi

Identifiers

PMID32418003
OpenAlexW3024612616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.