ArticleJournal of Alzheimer's disease : JAD2020
Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer's Disease Gene Expression Data.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- IQSPred-PLM: An Interpretable Quorum Sensing Peptides Prediction Model Based on Protein Language Model.Interdisciplinary sciences, computational life sciences · 2026Article
- Mechanistic insights into piperlongumine's neuroprotective role against cisplatin-induced neuropathy: a network pharmacology, molecular dynamics, and experimental approach.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Identification of Resistance Loci to Avian Leukosis via Genome-Wide Association Analysis in Chengkou Mountain Chickens.Animals : an open access journal from MDPI · 2025Article
- AlzGenPred - CatBoost-based gene classifier for predicting Alzheimer's disease using high-throughput sequencing data.Scientific reports · 2024Article
- Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology.RNA biology · 2024Article
- Exploring automatic inconsistency detection for literature-based gene ontology annotation.Bioinformatics (Oxford, England) · 2022Article
- Gene Ontology curation of the blood-brain barrier to improve the analysis of Alzheimer's and other neurological diseases.Database : the journal of biological databases and curation · 2021Article
- UniProt: the universal protein knowledgebase in 2021.Nucleic acids research · 2021Article
- RNAcentral 2021: secondary structure integration, improved sequence search and new member databases.Nucleic acids research · 2021Article
- Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats.Frontiers in veterinary science · 2021Article
- Term Matrix: a novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns.Open biology · 2020Article
- A Coordinated Approach by Public Domain Bioinformatics Resources to Aid the Fight Against Alzheimer's Disease Through Expert Curation of Key Protein Targets.Journal of Alzheimer's disease : JAD · 2020Article
- Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer Metastasis Biomarkers.Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundGene Ontology (GO) is a major bioinformatic resource used for analysis of large biomedical datasets, for example from genome-wide association studies, applied universally across biological fields, including Alzheimer's disease (AD) research.
objectiveWe aim to demonstrate the applicability of GO for interpretation of AD datasets to improve the understanding of the underlying molecular disease mechanisms, including the involvement of inflammatory pathways and dysregulated microRNAs (miRs).
methodsWe have undertaken a systematic full article GO annotation approach focused on microglial proteins implicated in AD and the miRs regulating their expression. PANTHER was used for enrichment analysis of previously published AD data. Cytoscape was used for visualizing and analyzing miR-target interactions captured from published experimental evidence.
resultsWe contributed 3,084 new annotations for 494 entities, i.e., on average six new annotations per entity. This included a total of 1,352 annotations for 40 prioritized microglial proteins implicated in AD and 66 miRs regulating their expression, yielding an average of twelve annotations per prioritized entity. The updated GO resource was then used to re-analyze previously published data. The re-analysis showed novel processes associated with AD-related genes, not identified in the original study, such as 'gliogenesis', 'regulation of neuron projection development', or 'response to cytokine', demonstrating enhanced applicability of GO for neuroscience research.
conclusionsThis study highlights ongoing development of the neurobiological aspects of GO and demonstrates the value of biocuration activities in the area, thus helping to delineate the molecular bases of AD to aid the development of diagnostic tools and treatments.
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