ArticleJournal of Alzheimer's disease : JAD2020
Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Cognitive screening biases in a secondary prevention Alzheimer's disease clinical trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Non-amnestic initial symptoms may be less prevalent in African American than White participants with Alzheimer's and mixed Lewy body and Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Racial and ethnic differences in white matter hypointensities: The role of vascular risk factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Receptive vocabulary is superior to education level to account for Black and White neuropsychological performance discrepancies.Journal of the International Neuropsychological Society : JINS · 2024Article
- Neuropathological Lesions and Cognitive Abilities in Black and White Older Adults in Brazil.JAMA network open · 2024Article
- White matter hyperintensities in diverse populations: A systematic review of literature in the United States.Cerebral circulation - cognition and behavior · 2024Review
- Cognitive Phenotypes of HIV Defined Using a Novel Data-driven Approach.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022Article
- Sex differences in predictors and regional patterns of brain age gap estimates.Human brain mapping · 2022Article
- Association of Healthy Lifestyles With Risk of Alzheimer Disease and Related Dementias in Low-Income Black and White Americans.Neurology · 2022Article
- Gradient and Acceleration of Decline in Physical and Cognitive Functions in Older Adults: A Disparity Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Article
- Culture, Ethnicity, and Level of Education in Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Alzheimer disease in African American individuals: increased incidence or not enough data?Nature reviews. Neurology · 2022Review
- Immune markers are associated with cognitive performance in a multiethnic cohort: The Northern Manhattan Study.Brain, behavior, and immunity · 2021Article
- Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project.Alzheimer's research & therapy · 2021Article
- Recent Advances in Imaging of Preclinical, Sporadic, and Autosomal Dominant Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Differences in Alzheimer's Disease and Related Dementias Pathology Among African American and Hispanic Women: A Qualitative Literature Review of Biomarker Studies.Frontiers in systems neuroscience · 2021Review
- Trajectory of Cognitive Decline Across Different Racial/Ethnic Groups: The Role of Edentulism.Research on agingArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundBlack Americans are approximately twice as likely to develop dementia as compared to White Americans and the magnitude of this disparity is often attributed to a variety of factors that include psychosocial and vascular risk factors. However, less is known about the potential contribution of Alzheimer's disease pathological differences.
objectiveTo examine potential differences incross-sectional and longitudinal cognitive performance in black and white participants who were clinically normal at baseline.
methods296 participants (48 African-American/black participants) underwent MRI and amyloid PET at baseline. Linear mixed models were used to examine the main effects of race, years of education, reading ability, Framingham Heart Study cardiovascular risk score (FHS-CVD), white matter hyperintensities (WMH), and amyloid (Aβ) burden on the Preclinical Alzheimer Cognitive Composite-5 (PACC5).
resultsLower levels of educationalattainment and reading ability were found for blacks compared to whites. By contrast, no differences in FHS-CVD, WMH, or Aβ were found by racial group. Baseline differences in PACC5 score were attenuated after adjusting for educationalfactors, vascular factors, and Aβ, but remained lower for blacks compared to whites (β= -0.24, p = 0.014). Further, blacks demonstrated a faster rate of PACC5 decline longitudinally compared to whites (β = -0.055, p = 0.025) after adjusting for covariates.
conclusionAccounting for educationalfactors, vascular factors, and Aβ burden diminished, but did not eliminate, racial differences in PACC5 performance longitudinally. Understanding potential differences in longitudinal cognitive outcomes by race may be important for upcoming secondary prevention trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.