ArticleCancer biomarkers : section A of Disease markers2020
Higher platelet distribution width is associated with unfavorable prognosis in ovarian cancer.
Article in Cancer biomarkers : section A of Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Revisiting the association between pretreatment thrombocytosis and cancer survival outcomes: an umbrella review of meta-analyses.BMC cancer · 2024Pooled it
- U-shaped prognostic signature: baseline platelet count and morphological parameters predict ovarian cancer outcomes in a 265-patient cohort.Frontiers in oncology · 2026Article
- Association between the changing trends of platelet distribution width and in-hospital mortality in critically ill patients with sepsis: a multicenter study based on machine learning.BMC infectious diseases · 2025Article
- The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients.Renal failure · 2024Article
- The association of preoperative hematologic parameters with short-term clinical outcomes in rectal cancer: A feature importance analysis.Cancer medicine · 2024Article
- Article
- Preoperative PDW levels predict pulmonary metastasis in patients with hepatocellular carcinoma.BMC cancer · 2022Article
- Preoperative Platelet Distribution Width Represents a Novel Prognostic Biomarker in Patients With Nonmetastatic Renal Cell Carcinoma: A Retrospective Clinical Analysis.Frontiers in oncology · 2022Article
- Prognostic Impact of Platelet-Large Cell Ratio In Myelodysplastic Syndromes.Frontiers in oncology · 2022Article
- Effect of Rho GTPase activating protein 9 combined with preoperative ratio of platelet distribution width to platelet count on prognosis of patients with serous ovarian cancer.Translational cancer research · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOvarian cancer (OC) is one of the most malignant gynecological cancers. Platelets play a profound role in cancer growth and metastasis. Platelet distribution width (PDW) is an indicator of platelet activation and is altered in malignancies. However, the prognostic value of PDW in OC remains unclear. This present study aimed to investigate the predictive significance of PDW in OC.
methods221 OC patients, between January 2013 and December 2013, were included in this study. The correlations between PDW and clinicopathological features were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW.
resultsOf the 221 patients, increased PDW levels were observed in 163 (73.6%) patients. Kaplan-Meier analysis revealed that higher PDW levels were associated with poor progression-free survival and overall survival (both p< 0.001). Cox-regression analysis confirmed the independent predictive value of PDW on overall survival (HR = 2.820, 95% CI = 1.776-4.476, p< 0.001).
conclusionHigher PDW levels predict poor prognosis in patients with OC. Elevated PDW may be a novel target for therapy.
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