Evidence map›Paper›PMID 32417748›Full record

ArticleNeurobiology of aging2020

Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer's disease.

Harpreet Kaur, Kumi Nagamoto-Combs, Svetlana Golovko, Mikhail Y Golovko, Marilyn G Klug, Colin Kelly Combs

Open access · greenAbstract read
In one paragraph

Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  5. Review
  6. Review
  7. Article
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  11. Article
  12. Review
  13. Review
  14. Gut microbial metabolism in Alzheimer's disease and related dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  15. Review
  16. The brain pathobiome in Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  17. Review
  18. Zeolite and Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Harpreet KaurDepartment of Biomedical Sciences, University of North Dakota, School of Medicine & Health Sciences, Grand Forks, ND, USA.
Kumi Nagamoto-CombsDepartment of Pathology, University of North Dakota, School of Medicine & Health Sciences, Grand Forks, ND, USA.
Svetlana GolovkoDepartment of Biomedical Sciences, University of North Dakota, School of Medicine & Health Sciences, Grand Forks, ND, USA.
Mikhail Y GolovkoDepartment of Biomedical Sciences, University of North Dakota, School of Medicine & Health Sciences, Grand Forks, ND, USA.
Marilyn G KlugDepartment of Population Health, University of North Dakota, School of Medicine & Health Sciences, Grand Forks, ND, USA.
Colin Kelly CombsDepartment of Biomedical Sciences, University of North Dakota, School of Medicine & Health Sciences, Grand Forks, ND, USA. Electronic address: colin.combs@und.edu.
University of North Dakota · US

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Chris Jurgens · 2012 to 2026
$53.0M
Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BRADLEY, DAVID S. · 2016 to 2025
$19.9M
Mechanisms of exposure-induced tissue functional and pathological changes in a mouse model of Alzheimer's DiseaseR01AG057046 · NIA · OHIO STATE UNIVERSITY · PI COMBS, COLIN K, DEL MONTE, FEDERICA · 2017 to 2021
$4.0M
Brain-Gut Communication in Alzheimer's DiseaseR01AG048993 · NIA · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2015 to 2019
$1.4M
NIA NIH HHS R01 AG048993NIA NIH HHS R01 AG057046NIGMS NIH HHS P20 GM103442NIGMS NIH HHS P20 GM113123NIGMS NIH HHS U54 GM128729
6 · The paper itself

Abstract

Evidence suggests that changes in intestinal microbiota may affect the central nervous system. However, it is unclear whether alteration of intestinal microbiota affects progression of Alzheimer's disease (AD). To understand this, wild-type control (C57BL/6) mice were compared with the App

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBile Acids and SaltsBrainCytokinesDisease Models, AnimalEicosanoidsFemaleGastrointestinal MicrobiomeGliosisInflammationMice, Inbred C57BLMice, TransgenicProbioticsAmyloid beta-PeptidesBile Acids and SaltsCytokinesEicosanoidsAlzheimer’s diseaseApp(NL-G-F) knock-in miceBile acidsGut microbiomeIntestinal inflammationNeuroinflammationProbioticProstaglandinsVSL#3

Identifiers

PMID32417748
PMCPMC7269849
OpenAlexW3016826587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.