Evidence map›Paper›PMID 32417536›Full record

ArticleBone2020

Deletion of α-Synuclein in Prrx1-positive cells causes partial loss of function in the central nervous system (CNS) but does not affect ovariectomy induced bone loss.

Carolina A Figueroa, Pratima Bajgain, J Patrizia Stohn, Arturo Hernandez, Daniel J Brooks, Karen L Houseknecht, Clifford J Rosen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Parkinson's in the bone.Cell & bioscience · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carolina A FigueroaMaine Medical Center Research Institute, MMCRI, Scarborough, ME, USA.. Electronic address: cfigueroa@mmc.org.
Pratima BajgainMaine Medical Center Research Institute, MMCRI, Scarborough, ME, USA.. Electronic address: pratima.bajgain@maine.edu.
J Patrizia StohnMaine Medical Center Research Institute, MMCRI, Scarborough, ME, USA.. Electronic address: stohnp@mmc.org.
Arturo HernandezMaine Medical Center Research Institute, MMCRI, Scarborough, ME, USA.. Electronic address: hernaa@mmc.org.
Daniel J BrooksCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA. Electronic address: djbrooks@partners.org.
Karen L HouseknechtDepartment of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME, USA.. Electronic address: khouseknecht@une.edu.
Clifford J RosenMaine Medical Center Research Institute, MMCRI, Scarborough, ME, USA.. Electronic address: rosenc@mmc.org.
Beth Israel Deaconess Medical Center · USUniversity of New England · US

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI CLIFFORD JAMES ROSEN · 2017 to 2026
$51.6M
The role of night shift work in metabolic disorders during and after pregnancyP20GM121301 · NIGMS · MAINEHEALTH · PI Lucy Liaw · 2017 to 2026
$25.1M
Genetic analysis of bone strengthR01AR068345 · NIAMS · UNIVERSITY OF VIRGINIA · PI FARBER, CHARLES R, HOROWITZ, MARK C · 2016 to 2020
$3.1M
NIAMS NIH HHS R01 AR068345NIGMS NIH HHS P20 GM121301NIGMS NIH HHS U54 GM115516
6 · The paper itself

Abstract

α-Synuclein is a small 140 amino acid polypeptide encoded by the Snca gene that is highly expressed in neural tissue, but it is also found in osteoblasts, erythroblasts, macrophages, and adipose tissue. Previously, using co-expression network analysis we found that Snca was a key regulator of skeletal homeostasis, and its deletion partially prevented bone loss after ovariectomy (OVX). Here we tested the hypothesis that Snca deletion in mesenchymal progenitors using the Prrx1Cre (Prrx1, Paired-related homeobox 1) limb enhancer would protect bone mass after OVX. Prrx1Cre;Snca

Indexed as

alpha-SynucleinBone Diseases, MetabolicAnimalsBone DensityCentral Nervous SystemFemaleGene DeletionHomeodomain ProteinsMaleMiceOvariectomyalpha-SynucleinHomeodomain ProteinsPrrx1 protein, mouseSnca protein, mouseAnxietyEstrogen-deficiencyObesityOsteoporosisOvariectomyα-Synuclein

Identifiers

PMID32417536
PMCPMC8260189
OpenAlexW3024379792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.