Evidence map›Paper›PMID 32416725›Full record

ArticleBMC complementary medicine and therapies2020

Psychopharmacological effects of riparin III from Aniba riparia (Nees) Mez. (Lauraceae) supported by metabolic approach and multivariate data analysis.

Sócrates Golzio Dos Santos, Isis Fernandes Gomes, Adriana Maria Fernandes de Oliveira Golzio, Augusto Lopes Souto, Marcus Tullius Scotti, Josean Fechine Tavares, Stanley Juan Chavez Gutierrez, Reinaldo Nóbrega de Almeida, José Maria Barbosa-Filho, Marcelo Sobral da Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sócrates Golzio Dos SantosInstituto de Pesquisa de Fármacos e Medicamentos - IPeFarM, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil.
Isis Fernandes GomesInstituto de Pesquisa de Fármacos e Medicamentos - IPeFarM, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil.
Adriana Maria Fernandes de Oliveira GolzioDepartamento de Tecnologia de Alimentos, Centro de Tecnologia e Desenvolvimento Regional, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil.
Augusto Lopes SoutoInstituto de Pesquisa de Fármacos e Medicamentos - IPeFarM, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil.
Marcus Tullius ScottiInstituto de Pesquisa de Fármacos e Medicamentos - IPeFarM, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil.
Josean Fechine TavaresInstituto de Pesquisa de Fármacos e Medicamentos - IPeFarM, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil.
Stanley Juan Chavez GutierrezInstituto de Pesquisa de Fármacos e Medicamentos - IPeFarM, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil.
Reinaldo Nóbrega de AlmeidaInstituto de Pesquisa de Fármacos e Medicamentos - IPeFarM, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil.
José Maria Barbosa-FilhoInstituto de Pesquisa de Fármacos e Medicamentos - IPeFarM, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil.
Marcelo Sobral da SilvaInstituto de Pesquisa de Fármacos e Medicamentos - IPeFarM, Universidade Federal da Paraíba, João Pessoa, PB, 58051-900, Brazil. marcelosobral.ufpb@gmail.com.ORCID http://orcid.org/0000-0003-1368-3245
Universidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently there is a high prevalence of humor disorders such as anxiety and depression throughout the world, especially concerning advanced age patients. Aniba riparia (Nees) Mez. (Lauraceae), popular known as "louro", can be found from the Amazon through Guianas until the Andes. Previous studies have already reported the isolation of alkamide-type alkaloids such as riparin III (O-methyl-N-2,6-dyhydroxy-benzoyl tyramine) which has demonstrated anxiolytic and antidepressant-like effects in high doses by intraperitoneal administration.

methodsExperimental protocol was conducted in order to analyze the anxiolytic-like effect of riparin III at lower doses by intravenous administration to Wistar rats (Rattus norvegicus) (n = 5). The experimental approach was designed to last 15 days, divided in 3 distinct periods of five days: control, anxiogenic and treatment periods. The anxiolytic-like effect was evaluated by experimental behavior tests such as open field and elevated plus-maze test, combined with urine metabolic footprint analysis. The urine was collected daily and analyzed by

resultsIt was observed on treatment group that cortisol, biomarker related to physiological stress was reduced, indicating anxiolytic-like effect of riparin III, probably through activation of 5-HT

conclusion

Indexed as

LauraceaeAdministration, IntravenousAnimalsAnti-Anxiety AgentsBehavior, AnimalBenzamidesBiomarkersBrazilHydrocortisoneMaze LearningMultivariate AnalysisRatsRats, WistarTyramineAnti-Anxiety AgentsBenzamidesBiomarkersHydrocortisoneriparin IIITyramineAniba ripariaAnxiety animal modelFootprintMetabolomics analysisRiparinUrine

Identifiers

PMID32416725
PMCPMC7229579
OpenAlexW3025773632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.