Evidence map›Paper›PMID 32416289›Full record

Observational studyBrain, behavior, and immunity2020

Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection.

Claudio Liguori, Mariangela Pierantozzi, Matteo Spanetta, Loredana Sarmati, Novella Cesta, Marco Iannetta, Josuel Ora, Grazia Genga Mina, Ermanno Puxeddu, Ottavia Balbi and 5 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 19 pooled it
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 19 syntheses or guidelines pooled it, 225 citations in OpenAlex.

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  13. Sleep problems during the COVID-19 pandemic by population: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
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  19. Neurological manifestations of coronavirus infections - a systematic review.Annals of clinical and translational neurology · 2020
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  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Claudio LiguoriNeurology Unit, University Hospital "Tor Vergata", Rome, Italy; Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy. Electronic address: dott.claudioliguori@yahoo.it.
Mariangela PierantozziNeurology Unit, University Hospital "Tor Vergata", Rome, Italy; Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Matteo SpanettaNeurology Unit, University Hospital "Tor Vergata", Rome, Italy.
Loredana SarmatiDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy; Infectious Diseases Clinic, University Hospital "Tor Vergata", Rome, Italy.
Novella CestaInfectious Diseases Clinic, University Hospital "Tor Vergata", Rome, Italy.
Marco IannettaDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy; Infectious Diseases Clinic, University Hospital "Tor Vergata", Rome, Italy.
Josuel OraDivision of Respiratory Medicine, University Hospital "Tor Vergata", Rome, Italy.
Grazia Genga MinaOccupational Medicine Department, University of Rome "Tor Vergata",Rome, Italy.
Ermanno PuxedduDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Ottavia BalbiOccupational Medicine Department, University of Rome "Tor Vergata",Rome, Italy.
Gabriella PezzutoDivision of Respiratory Medicine, University Hospital "Tor Vergata", Rome, Italy.
Andrea MagriniOccupational Medicine Department, University of Rome "Tor Vergata",Rome, Italy.
Paola RoglianiDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Massimo AndreoniDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy; Infectious Diseases Clinic, University Hospital "Tor Vergata", Rome, Italy.
Nicola Biagio MercuriNeurology Unit, University Hospital "Tor Vergata", Rome, Italy; Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy; IRCCS Santa Lucia Foundation, Rome, Italy.
University of Rome Tor Vergata · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCoronavirus disease 2019 (COVID-19) represents a novel pneumonia leading to severe acute respiratory syndrome (SARS). Recent studies documented that SARS-Coronavirus2 (SARS-CoV2), responsible for COVID-19, can affect the nervous system. The aim of the present observational study was to prospectively assess subjective neurological symptoms (sNS) in patients with SARS-CoV2 infection.

methodsWe included patients hospitalized at the University Hospital of Rome "Tor Vergata", medical center dedicated to the treatment of patients with COVID-19 diagnosis, who underwent an anamnestic interview about sNS consisting of 13 items, each related to a specific symptom, requiring a dichotomized answer.

resultsWe included 103 patients with SARS-CoV2 infection. Ninety-four patients (91.3%) reported at least one sNS. Sleep impairment was the most frequent symptom, followed by dysgeusia, headache, hyposmia, and depression. Women more frequently complained hyposmia, dysgeusia, dizziness, numbeness/paresthesias, daytime sleepiness, and muscle ache. Moreover, muscle ache and daytime sleepiness were more frequent in the first 2 days after admission. Conversely, sleep impairment was more frequent in patients with more than 7 days of hospitalization. In these patients we also documented higher white blood cells and lower C-reactive protein levels. These laboratory findings correlated with the occurrence of hyposmia, dysgeusia, headache, daytime sleepiness, and depression.

conclusionsPatients with SARS-CoV2 infection frequently present with sNS. These symptoms are present from the early phases of the disease. The possibly intrinsic neurotropic properties of SARS-CoV2 may justify the very high frequency of sNS. Further studies targeted at investigating the consequences of SARS-CoV2 infection on the CNS should be planned.

Indexed as

SleepinessAdultAgedBetacoronavirusCoronavirus InfectionsCOVID-19C-Reactive ProteinDepressionDizzinessDysgeusiaFemaleHeadacheHospitalizationHumansHypesthesiaItalyC-Reactive ProteinCentral nervous systemCOVID-19Daytime sleepinessDysgeusiaHyposmiaNeurological symptomsNeurologySARS-CoV2 infectionSexSleep impairment

Identifiers

PMID32416289
PMCPMC7235586
OpenAlexW3025588373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.