Evidence map›Paper›PMID 32416283›Full record

ArticlePapillomavirus research (Amsterdam, Netherlands)2020

Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia.

Felix Jede, Theresa Brandt, Molla Gedefaw, Solomon Berhe Wubneh, Tamrat Abebe, Brhanu Teka, Kassahun Alemu, Binyam Tilahun, Temesgen Azemeraw, Abebaw Gebeyehu and 12 more

Abstract read
In one paragraph

Article in Papillomavirus research (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Felix JedeApplied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: felix@jede.name.
Theresa BrandtApplied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: theresa-brandt@gmx.net.
Molla GedefawAmhara Regional Health Bureau, Bahir Dar, Ethiopia. Electronic address: bdfam72@gmail.com.
Solomon Berhe WubnehDepartment of Obstetrics and Gynecology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: solomonbe2310@gmail.com.
Tamrat AbebeDepartment of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. Electronic address: tamrat.abebe@aau.edu.et.
Brhanu TekaDepartment of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. Electronic address: brhanu.teka@aau.edu.et.
Kassahun AlemuDepartment of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: kassalemu@gmail.com.
Binyam TilahunDepartment of Health Informatics, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: binigcms@gmail.com.
Temesgen AzemerawDepartment of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: tazemeraw@gmail.com.
Abebaw GebeyehuAmhara Regional Health Bureau, Bahir Dar, Ethiopia. Electronic address: gabebaw2worku@gmail.com.
Dietmar SchmidtDepartment of Cytopathology, Institute of Pathology, Viersen, Germany. Electronic address: dischmi57@gmail.com.
Aleksandra PesicClinic for Gynecology, Charité - Berlin Institute of Health, Charite - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany. Electronic address: aleksandra.pesic@charite.de.
Andreas M KaufmannClinic for Gynecology, Charité - Berlin Institute of Health, Charite - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany. Electronic address: andreas.kaufmann@charite.de.
Bewketu AbebeDepartment of Pathology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: dischmi57@gmail.com.
Zelalem AyichewDepartment of Obstetrics and Gynecology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: zelalem538@yahoo.com.
Michael ByczkowskiSAP SE, Walldorf, Germany. Electronic address: michael.byczkowski@sap.com.
Timoté VaucherÉcole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Electronic address: timote.vaucher@epfl.ch.
Heike SartorApplied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: heike.sartor@med.uni-heidelberg.de.
Gashaw AndargieDepartment of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. Electronic address: gashawab@gmail.com.
Till BärnighausenHeidelberg Institute of Global Health (HIGH), Faculty of Medicine and University Hospital, Heidelberg University, Heidelberg, Germany; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, USA; Africa Health Research Institute (AHRI), Somkhele and Durban, South Africa. Electronic address: till.baernighausen@uni-heidelberg.de.
Magnus von Knebel DoeberitzApplied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: magnus.knebel-doeberitz@med.uni-heidelberg.de.
Hermann BussmannApplied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: Hermann.Bussmann@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary HPV testing and triage of HPV-positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community-based screening in resource-poor communities, provided a robust tracking system is in place. A cervical cancer screening campaign was conducted in a rural community in Ethiopia. All women aged 25-65 years were offered genital self-sampling using the Evalyn Brush®. Samples were HPV-DNA-tested at a central laboratory. Key indicators were captured on tablet computers and linked by a cloud-based information system. HPV-positive women were examined at the local clinic using portable colposcopy, p16/Ki-67 dual stain cytology and biopsy examination. CIN2+ women were referred for LEEP to the referral hospital. Of 749 enumerated age-eligible women 634 (85%, (95% CI 82-88)) consented to screening, 429 samples were adequate for HPV testing, giving a total testing coverage of 57% (95% CI 53-62). The hrHPV prevalence was 14% (95% CI 5-22), 72% (95% CI 60-84) attended the clinic for a triage examination. Home-based HPV-DNA self-sampling and clinic-based triage assisted by cloud-based information technology is feasible in rural Ethiopia. Key components of such strategy are broad community awareness, high competency of community workers, and establishment of an adequate self-sampling and HPV-DNA testing platform.

Indexed as

Cloud ComputingAdultAgedEarly Detection of CancerElectronic Data ProcessingEthiopiaFemaleHealth PromotionHumansMiddle AgedPapillomavirus InfectionsPilot ProjectsRural PopulationSelf-TestingSpecimen HandlingUterine Cervical DysplasiaCervical cancer screeningCommunityeHealthElectronic data systemEthiopiaHome-basedHPV testingp16/ki-67 dual stain cytologyRuralSelf-sampling

Identifiers

PMID32416283
PMCPMC7240728

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.