ReviewAdvanced drug delivery reviews2020
Orally ingestible medical devices for gut engineering.
Review in Advanced drug delivery reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Magnetically controlled delivery capsule endoscopy for precise drug delivery to intestinal lesions.Drug delivery and translational research · 2026Article
- An ingestible light source for deep photoacoustic imaging.Photoacoustics · 2026Article
- Development of pH-Dependent Magnetically Actuated Millirobot for Colon-Targeted Delivery of Diverse Drug Types.Micromachines · 2026Article
- Colloidal Interactions in Simulated Intestinal Fluids: Implications for Oral Drug Delivery at the Nanoscale.Small science · 2025Article
- Regulatory Guidelines for the Analysis of Therapeutic Peptides and Proteins.Journal of peptide science : an official publication of the European Peptide Society · 2025Review
- BAKE: a novel framework for iterative security design for identifying criminally-exploitable vulnerabilities in biotechnology products.Crime science · 2025Article
- A Low-Friction Capsule Robot with Drive-Control-Sensing Integration for Gastrointestinal Lesion Detection.Research (Washington, D.C.) · 2025Article
- Untethered bistable origami crawler for confined applications.Communications engineering · 2024Article
- Colon or semicolon: gut sampling microdevices for omics insights.NPJ biofilms and microbiomes · 2024Review
- Oral administration microrobots for drug delivery.Bioactive materials · 2024Review
- Article
- Review
- Bioadhesive Tannic-Acid-Functionalized Zein Coating Achieves Engineered Colonic Delivery of IBD Therapeutics via Reservoir Microdevices.Pharmaceutics · 2022Article
- Ingestible Functional Magnetic Robot with Localized Flexibility (MR-LF).Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2022Article
- A Review of Digital Health and Biotelemetry: Modern Approaches towards Personalized Medicine and Remote Health Assessment.Journal of personalized medicine · 2022Review
- State of the Art in Smart Portable, Wearable, Ingestible and Implantable Devices for Health Status Monitoring and Disease Management.Sensors (Basel, Switzerland) · 2022Review
- Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies.Theranostics · 2022Review
- Research-Based Product Innovation to Address Critical Unmet Needs of Patients with Inflammatory Bowel Diseases.Inflammatory bowel diseases · 2021Article
- Article
- Fabrication and Applications of Microfluidic Devices: A Review.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orally ingestible medical devices provide significant advancement for diagnosis and treatment of gastrointestinal (GI) tract-related conditions. From micro- to macroscale devices, with designs ranging from very simple to complex, these medical devices can be used for site-directed drug delivery in the GI tract, real-time imaging and sensing of gut biomarkers. Equipped with uni-direction release, or self-propulsion, or origami design, these microdevices are breaking the barriers associated with drug delivery, including biologics, across the GI tract. Further, on-board microelectronics allow imaging and sensing of gut tissue and biomarkers, providing a more comprehensive understanding of underlying pathophysiological conditions. We provide an overview of recent advances in orally ingestible medical devices towards drug delivery, imaging and sensing. Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micromanipulation of the gut are discussed. We have critically examined the relationship between materials-device design-pharmacological responses with respect to existing regulatory guidelines and provided a clear roadmap for the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.