ArticleDevelopmental science2021
Beyond family-level adversities: Exploring the developmental timing of neighborhood disadvantage effects on the brain.
Article in Developmental science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- A research agenda for understanding how social inequality is linked to brain structure and function.Nature human behaviour · 2024Pooled it
- Polymethylation scores for prenatal maternal smoke exposure persist until age 15 and are detected in saliva in the Fragile Families and Child Wellbeing cohort.Epigenetics · 2022Pooled it
- Food Insecurity and Child Development: A State-of-the-Art Review.International journal of environmental research and public health · 2021Pooled it
- Sleep and participation in extracurricular activities moderate associations between low SES and brain structure and functional connectivity.Developmental cognitive neuroscience · 2026Article
- Type and developmental timing of childhood adversity predicts psychopathology symptoms in a South African birth cohort.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Prenatal experience of greater neighborhood disadvantage is associated with altered fetal volumetric brain growth in utero.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- The association between four neighborhood disadvantage indices and child chronic health classifications.Pediatric research · 2026Article
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Social determinants impact both viral infections and brain development.Pediatric research · 2025Review
- Neighborhood air quality, psychobiological reactivity, and mental health across adolescence.Environmental science and pollution research international · 2025Article
- Associations among socioeconomic disadvantage, longitudinal changes in within-network connectivity, and academic outcomes in the ABCD study.Developmental cognitive neuroscience · 2025Article
- Environmental Adversity Is Associated With Attenuated Positive Symptoms and Complex Cognition in a Long-term Follow-up of the Philadelphia Neurodevelopmental Cohort.Schizophrenia bulletin · 2025Article
- Fine particulate matter air pollution and longitudinal gray matter development changes during early adolescence: variation by neighborhood disadvantage level.Environment international · 2025Article
- Neighborhood opportunity and response to psychotherapy in anxious youth.Psychiatry research · 2025Article
- The role of socioeconomic status in shaping associations between sensory association cortex and prefrontal structure and implications for executive function.Developmental cognitive neuroscience · 2025Article
- Evidence for Environmental Risk Factors and Cumulative Stress Linking Racial/Ethnic Identity and Psychotic-Like Experiences in ABCD Study Data.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Functional Brain Connectivity Predictors of Prospective Substance Use Initiation and Their Environmental Correlates.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- The growing interdisciplinarity of developmental psychopathology: Implications for science and training.Development and psychopathology · 2024Article
- Increasing diversity in neuroimaging research: Participant-driven recommendations from a qualitative study of an under-represented sample.Developmental cognitive neuroscience · 2024Article
- Hierarchical individual variation and socioeconomic impact on personalized functional network topography in children.BMC medicine · 2024Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
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Abstract
A growing literature suggests that adversity is associated with later altered brain function, particularly within the corticolimbic system that supports emotion processing and salience detection (e.g., amygdala, prefrontal cortex [PFC]). Although neighborhood socioeconomic disadvantage has been shown to predict maladaptive behavioral outcomes, particularly for boys, most of the research linking adversity to corticolimbic function has focused on family-level adversities. Moreover, although animal models and studies of normative brain development suggest that there may be sensitive periods during which adversity exerts stronger effects on corticolimbic development, little prospective evidence exists in humans. Using two low-income samples of boys (n = 167; n = 77), Census-derived neighborhood disadvantage during early childhood, but not adolescence, was uniquely associated with greater amygdala, but not PFC, reactivity to ambiguous neutral faces in adolescence and young adulthood. These associations remained after accounting for several family-level adversities (e.g., low family income, harsh parenting), highlighting the independent and developmentally specific neural effects of the neighborhood context. Furthermore, in both samples, indicators measuring income and poverty status of neighbors were predictive of amygdala function, suggesting that neighborhood economic resources may be critical to brain development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.