Evidence map›Paper›PMID 32416012›Full record

ArticleMagnetic resonance in medicine2020

Investigating the origin of pH-sensitive magnetization transfer ratio asymmetry MRI contrast during the acute stroke: Correction of T

Limin Wu, Liang Jiang, Phillip Zhe Sun

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  3. Quasi-steady-state (QUASS) reconstruction enhances TMagnetic resonance in medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Limin WuNeuroscience Center and Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
Liang JiangDepartment of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwestern Medical University, Luzhou, Sichuan, China.
Phillip Zhe SunYerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.ORCID 0000-0003-4872-1192

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Establishment of fast pH MRI for imaging metabolic injury during acute strokeR01NS083654 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Phillip Zhe Sun · 2013 to 2026
$4.0M
NIH HHS P51 OD011132NINDS NIH HHS R01 NS083654
6 · The paper itself

Abstract

purposeAmide proton transfer (APT) MRI is promising to serve as a surrogate metabolic imaging biomarker of acute stroke. Although the magnetization transfer ratio asymmetry (MTR

methodsMultiparametric MRI, including T

resultsThe conventional Z-spectrum signal change at -3.5 ppm dominates that at +3.5 ppm (-1.16 ± 0.39% vs. 0.76 ± 0.26%, P < .01) following acute stroke. In comparison, the magnitude of ΔR

conclusionOur study shows that after the relaxation-effect correction, the APT effect is the dominant contributing factor to pH-weighted MTR

Indexed as

ProtonsStrokeAmidesAnimalsBrainHydrogen-Ion ConcentrationMagnetic Resonance ImagingRatsAmidesProtonsacute strokeamide proton transferapparent exchange-dependent relaxationchemical exchange saturation transfermagnetization transfer and relaxation normalized APTpH

Identifiers

PMID32416012
PMCPMC7402019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.