ArticlePlant biotechnology journal2020
A fungal effector and a rice NLR protein have antagonistic effects on a Bowman-Birk trypsin inhibitor.
Article in Plant biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 76 citations in OpenAlex.
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- The CCCH-tandem zinc-finger protein OsTZF1 positively regulates basal immunity but suppresses Piz-t-mediated blast resistance in rice.Plant communications · 2026Article
- Ubiquitination of susceptibility factor drives broad-spectrum resistance.Science China. Life sciences · 2026Article
- Genomic insights into sheath blight resistance: leveraging natural variation in the Bengal-Assam-Aus rice panel for multi-season association mapping.Frontiers in plant science · 2026Article
- Silenced cutters: mechanisms and effects of protease inhibition in plant-pathogen interactions.Journal of experimental botany · 2025Review
- Biomarker genes for model-based prediction of drought-stress perception levels in rice.BMC plant biology · 2025Article
- The Role ofInternational journal of molecular sciences · 2025Article
- Rice E3 ubiquitin ligases: From key modulators of host immunity to potential breeding applications.Plant communications · 2024Review
- Exploring the molecular mechanisms of rice blast resistance and advances in breeding for disease tolerance.Molecular biology reports · 2024Review
- Leaf rust (Puccinia recondita f. sp. secalis) triggers substantial changes in rye (Secale cereale L.) at the transcriptome and metabolome levels.BMC plant biology · 2024Article
- RNAi-Mediated Suppression ofInternational journal of molecular sciences · 2024Article
- The roles ofFrontiers in plant science · 2024Review
- Article
- An Ustilaginoidea virens glycoside hydrolase 42 protein is an essential virulence factor and elicits plant immunity as a PAMP.Molecular plant pathology · 2023Article
- The E3 ubiquitin ligase OsRGLG5 targeted by the Magnaporthe oryzae effector AvrPi9 confers basal resistance against rice blast.Plant communications · 2023Article
- Rice ubiquitin-conjugating enzyme OsUbc13 negatively regulates immunity against pathogens by enhancing the activity of OsSnRK1a.Plant biotechnology journal · 2023Article
- In order to lower the antinutritional activity of serine protease inhibitors, we need to understand their role in seed development.Frontiers in plant science · 2023Article
- Proteo-Molecular Investigation of Cultivated Rice, Wild Rice, and Barley Provides Clues of Defense Responses againstBioengineering (Basel, Switzerland) · 2022Article
- APIP5 functions as a transcription factor and an RNA-binding protein to modulate cell death and immunity in rice.Nucleic acids research · 2022Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bowman-Birk trypsin inhibitors (BBIs) play important roles in animal and plant immunity, but how these protease inhibitors are involved in the immune system remains unclear. Here, we show that the rice (Oryza sativa) BBI protein APIP4 is a common target of a fungal effector and an NLR receptor for innate immunity. APIP4 exhibited trypsin inhibitor activity in vitro and in vivo. Knockout of APIP4 in rice enhanced susceptibility, and overexpression of APIP4 increased resistance to the fungal pathogen Magnaporthe oryzae. The M. oryzae effector AvrPiz-t interacted with APIP4 and suppressed APIP4 trypsin inhibitor activity. By contrast, the rice NLR protein Piz-t interacted with APIP4, enhancing APIP4 transcript and protein levels, and protease inhibitor activity. Our findings reveal a novel host defence mechanism in which a host protease inhibitor targeted by a fungal pathogen is protected by an NLR receptor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.