ArticleJournal of veterinary emergency and critical care (San Antonio, Tex. : 2001)2020
Effect of 7.5% hypertonic saline solution on whole blood coagulation in healthy dogs using thromboelastography.
Article in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Intravenous Fluid Administration and the Coagulation System.Frontiers in veterinary science · 2021Review
- Effect of 7.5% hypertonic saline solution on whole blood coagulation in healthy dogs using thromboelastography.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
objectiveTo evaluate the effects of 7.5% hypertonic saline solution (HSS) on whole blood coagulation in healthy dogs and to compare electrolyte and osmolality measurements between in vivo and in vitro dilution with HSS.
designExperimental study.
settingUniversity teaching hospital. ANIMALS: Twelve adult purpose-bred Beagles.
interventionsAll 12 dogs received 5 mL/kg 7.5% HSS at 1 mL/kg/min. After a 14-day washout period, 5 of these dogs were randomly selected and received the same volume of 0.9% NaCl. Blood samples were collected before infusion, immediately after infusion, and at 30, 60, and 90 minutes after infusion for the measurement of coagulation using thromboelastography. For comparison of electrolyte concentrations and osmolality between in vitro dilution and in vivo dilution of HSS, 6-mL blood samples were diluted with 7.5% HSS (1:18 ratio) at baseline. MEASUREMENTS AND MAIN
resultsNone of the thromboelastography variables differed significantly between the 7.5% HSS group and the 0.9% NaCl group. The sodium and chloride levels, and the osmolality, were significantly increased at all postinfusion time points compared to baseline, while those levels were significantly higher with in vitro dilution than all postinfusion time points. However, almost all the values gradually decreased and became similar to baseline values in case of in vivo dilution.
conclusionsThe clinically relevant dose of 7.5% HSS (5 mL/kg) did not affect whole blood coagulation significantly in healthy Beagles. Further studies are necessary to assess the effect of HSS on blood coagulation in canine patients with shock.
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