Evidence map›Paper›PMID 32415739›Full record

ArticleThe Journal of physiology2020

Identification and classification of interstitial cells in the mouse renal pelvis.

Nathan Grainger, Ryan S Freeman, Cameron C Shonnard, Bernard T Drumm, Sang Don Koh, Sean M Ward, Kenton M Sanders

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  4. Role of ANO1 CaPflugers Archiv : European journal of physiology · 2025
    Article
  5. Article
  6. The kidney stroma in development and disease.Nature reviews. Nephrology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nathan GraingerDepartment of Physiology & Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Ryan S FreemanDepartment of Physiology & Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.ORCID 0000-0003-0880-6642
Cameron C ShonnardDepartment of Physiology & Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.ORCID 0000-0002-0417-9154
Bernard T DrummDepartment of Physiology & Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Sang Don KohDepartment of Physiology & Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Sean M WardDepartment of Physiology & Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Kenton M SandersDepartment of Physiology & Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.ORCID 0000-0002-4196-1583
University of Nevada, Reno · US

Funding

Single Cell Molecular ExpressionP30GM110767 · NIGMS · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2014 to 2018
$5.4M
Pacemaker cells and mechanism in the renal pelvisR01DK124509 · NIDDK · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2020 to 2023
$1.9M
NIDDK NIH HHS R01 DK124509NIGMS NIH HHS P30 GM110767University of Nevada, Reno
6 · The paper itself

Abstract

key pointsPlatelet-derived growth factor receptor-α (PDGFRα) is a novel biomarker along with smooth myosin heavy chain for the pacemaker cells (previously termed 'atypical' smooth muscle cells) in the murine and cynomolgus monkey pelvis-kidney junction. PDGFRα ABSTRACT: Rhythmic contractions of the renal pelvis transport urine from the kidneys into the ureter. Specialized pacemaker cells, termed atypical smooth muscle cells (ASMCs), are thought to drive the peristaltic contractions of typical smooth muscle cells (TSMCs) in the renal pelvis. Interstitial cells (ICs) in close proximity to ASMCs and TSMCs have been described, but the role of these cells is poorly understood. The presence and distributions of platelet-derived growth factor receptor-α

Indexed as

Interstitial Cells of CajalAnimalsKidney PelvisMacaca fascicularisMiceMuscle, SmoothMyocytes, Smooth Muscleanoctamin-1atypical smooth muscle cellinterstitial cellsplatelet-derived growth factor receptor-α

Identifiers

PMID32415739
PMCPMC7771379
OpenAlexW3025135234

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.