ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2020
Technetium pyrophosphate nuclear scintigraphy for cardiac amyloidosis: Imaging at 1 vs 3 hours and planar vs SPECT/CT.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Diagnostic accuracy of bone scintigraphy imaging for transthyretin cardiac amyloidosis: systematic review and meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Pooled it
- Diagnostic performance of CMR, SPECT, and PET imaging for the detection of cardiac amyloidosis: a meta-analysis.BMC cardiovascular disorders · 2021Pooled it
- Agreement between SPECT/CT-derived autoplanar imaging and conventional planar imaging inAnnals of nuclear medicine · 2026Article
- Semi-quantitative evaluation of early phaseAnnals of nuclear medicine · 2026Article
- QuantitativeEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Rapid dynamic acquisition of cardiac amyloid radionuclide imaging.European journal of nuclear medicine and molecular imaging · 2026Article
- Cardiac magnetic resonance imaging and cardiac scintigraphy in the diagnosis of cardiac amyloidosis: A meta-analysis of 4866 patients.Journal of molecular and cellular cardiology plus · 2025Article
- The Accuracy of Technetium-99 m Pyrophosphate Imaging in Diagnosing Transthyretin Cardiac Amyloidosis and Its Impact on Patient Management.Current cardiology reports · 2025Review
- Impact of Region of Interest Size on Semi-Quantification of MyocardialAnnals of nuclear cardiology · 2025Article
- Performance ofAnnals of nuclear medicine · 2024Article
- Appraisal of amyloidosis imaging practices in the Middle East/North Africa (PYP-MENA).European heart journal. Imaging methods and practice · 2024Article
- Transthyretin amyloid cardiomyopathy disease burden quantified usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Comparison of cardio-focal and chest reconstruction of technetium-99m pyrophosphate scintigraphy for diagnosis of transthyretin cardiac amyloidosis: a quality assurance study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Reply to the letter: In the thick of it: highlighting the importance of SPECT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- In the thick of it: highlighting the importance of SPECT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prevalence of transthyretin amyloidosis among heart failure patients with preserved ejection fraction in Japan.ESC heart failure · 2023Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Echocardiographic indices of left ventricular function and filling pressure are not related to blood pool activity on pyrophosphate scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A Review of Current and Evolving Imaging Techniques in Cardiac Amyloidosis.Current treatment options in cardiovascular medicine · 2023Article
- Quantitation in ATTR cardiac amyloidosis: the next step is almost there!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMulti-societal consensus recommendations endorse both planar and single photon emission tomographic (SPECT) image acquisitions for the evaluation of cardiac amyloidosis. However, the correlation between planar and SPECT findings and the optimal timing of image acquisitions remain uncertain.
methodsThis is an analysis of 109 consecutive patients who underwent technetium pyrophosphate nuclear scintigraphy for the evaluation of cardiac amyloidosis. Patients were imaged at 1 and 3 hours after radiotracer injection using both planar and SPECT/CT, and the correlations between imaging protocols were compared.
resultsIn the overall cohort (median age 77 years, 75% male), 33 patients had radiotracer localized to the myocardium on SPECT/CT images. There was strong correlation between 1- and 3-hour planar heart-to-contralateral lung ratios (mean difference 0.07, r = 0.94). However, there was discordance between planar image interpretation (based upon semiquantitative score and H/CL ratio) and myocardial localization of radiotracer on SPECT/CT in 17 patients (16%). The pattern of SPECT/CT uptake was identical at 1 and 3 hours in all cases (32 diffuse, 1 focal).
conclusionThese data support the recommendation that SPECT/CT should be obtained in addition to planar images when performing nuclear scintigraphy for the detection of cardiac amyloidosis. A 1-hour planar and SPECT/CT protocol appears optimal.
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