Evidence map›Paper›PMID 32415582›Full record

ArticleJournal of biomolecular NMR2020

NMR mapping of the highly flexible regions of

Soyoung Cha, Weon Sup Lee, Joonhyeok Choi, Jong Geun Jeong, Ju Ryoung Nam, Jihong Kim, Hak-Nam Kim, Joon-Hwa Lee, Jin-San Yoo, Kyoung-Seok Ryu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of biomolecular NMR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Soyoung ChaProtein Structure Research Team, Korea Basic Science Institute, 162 Yeongudanji-Ro, Ochang-Eup, Cheongju-Si, Chungcheongbuk-Do, 28119, South Korea.
Weon Sup LeePharmAbcine, 2F, Research Building 2, 70, Yuseong-daero 1689 Beon-gil, Yuseong-gu, Daejeon, 34047, South Korea.
Joonhyeok ChoiProtein Structure Research Team, Korea Basic Science Institute, 162 Yeongudanji-Ro, Ochang-Eup, Cheongju-Si, Chungcheongbuk-Do, 28119, South Korea.
Jong Geun JeongPharmAbcine, 2F, Research Building 2, 70, Yuseong-daero 1689 Beon-gil, Yuseong-gu, Daejeon, 34047, South Korea.
Ju Ryoung NamPharmAbcine, 2F, Research Building 2, 70, Yuseong-daero 1689 Beon-gil, Yuseong-gu, Daejeon, 34047, South Korea.
Jihong KimNew Drug Development Center, Osong Medical Innovation Foundation, 123 Osongsaengmyeong-Ro, Osong-Eup, Cheongju-Si, Chungcheongbuk-Do, 28160, South Korea.
Hak-Nam KimProtein Structure Research Team, Korea Basic Science Institute, 162 Yeongudanji-Ro, Ochang-Eup, Cheongju-Si, Chungcheongbuk-Do, 28119, South Korea.
Joon-Hwa LeeDepartment of Chemistry and RINS, Gyeongsang National University, Jinju-si, Gyeongsangnam-Do, 52828, South Korea.
Jin-San YooPharmAbcine, 2F, Research Building 2, 70, Yuseong-daero 1689 Beon-gil, Yuseong-gu, Daejeon, 34047, South Korea. jinsan.yoo@pharmabcine.com.
Kyoung-Seok RyuProtein Structure Research Team, Korea Basic Science Institute, 162 Yeongudanji-Ro, Ochang-Eup, Cheongju-Si, Chungcheongbuk-Do, 28119, South Korea. ksryu@kbsi.re.kr.ORCID http://orcid.org/0000-0002-8422-6669
Korea Basic Science Institute · KRGreen Cross (South Korea) · KRGyeongsang National University · KRKorea University of Science and Technology · KROsong Medical Innovation Foundation · KR

Funding

Korea Basic Science Institute T39632National Research Foundation (KR) 2016R1A2B4015436Samsung Science & Technology Foundation (KR) SSTF-BA1701-10
6 · The paper itself

Abstract

Monoclonal antibody (mAb) drugs are clinically important for the treatment of various diseases. TTAC-0001 is under development as a new anti-cancer antibody drug targeting VEGFR-2. As the less severe toxicity of TTAC-0001 compared to Bevacizumab, likely due to the decreased in vivo half-life, seems to be related to its structural flexibility, it is important to map the exact flexible regions. Although the

Indexed as

Antibodies, Monoclonal, HumanizedCarbon IsotopesDisulfidesEscherichia coliImmunoglobulin Fab FragmentsIsopropyl ThiogalactosideIsotope LabelingNitrogen IsotopesNuclear Magnetic Resonance, BiomolecularPeriplasmRecombinant ProteinsReproducibility of ResultsVascular Endothelial Growth Factor Receptor-2Antibodies, Monoclonal, HumanizedCarbon-13Carbon IsotopesDisulfidesImmunoglobulin Fab FragmentsIsopropyl ThiogalactosideKDR protein, humanNitrogen-15Nitrogen IsotopesolinvacimabRecombinant ProteinsVascular Endothelial Growth Factor Receptor-2Antibody fabBackbone chemical shift NMR assignmentE. coli periplasmic expressionMonoclonal antibodyNMRTTAC-0001

Identifiers

PMID32415582
OpenAlexW3026018831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.