Evidence map›Paper›PMID 32415551›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

A deep neural network for fast and accurate scatter estimation in quantitative SPECT/CT under challenging scatter conditions.

Haowei Xiang, Hongki Lim, Jeffrey A Fessler, Yuni K Dewaraja

Open access · greenAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
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  8. CT-free attenuation and Monte-Carlo based scatter correction-guided quantitativeEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  9. Article
  10. Review
  11. ImprovingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  12. Review
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  14. Article
  15. Reducing scan time inJournal of applied clinical medical physics · 2023
    Article
  16. Article
  17. Training End-to-End Unrolled Iterative Neural Networks for SPECT Image Reconstruction.IEEE transactions on radiation and plasma medical sciences · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Haowei XiangElectrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-7598-9480
Hongki LimElectrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-2764-3730
Jeffrey A FesslerElectrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-9998-3315
Yuni K DewarajaDepartment of Radiology, University of Michigan, 1301 Catherine, 2276 Medical Science I/5610, Ann Arbor, MI, 48109, USA. yuni@med.umich.edu.ORCID 0000-0002-3920-6925
University of Michigan · US

Funding

Imaging and Dosimetry of Yttrium-90 for Personalized Cancer TreatmentR01EB022075 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DEWARAJA, YUNI K · 2016 to 2023
$4.7M
NIBIB NIH HHS R01 EB022075
6 · The paper itself

Abstract

purposeA major challenge for accurate quantitative SPECT imaging of some radionuclides is the inadequacy of simple energy window-based scatter estimation methods, widely available on clinic systems. A deep learning approach for SPECT/CT scatter estimation is investigated as an alternative to computationally expensive Monte Carlo (MC) methods for challenging SPECT radionuclides, such as

methodsA deep convolutional neural network (DCNN) was trained to separately estimate each scatter projection from the measured

resultsThe contrast recovery (CR) vs. noise and lung insert residual error vs. noise curves for images reconstructed with DCNN-SC and MC-SC estimates were similar. At the same noise level of 10% (across multiple realizations), the average sphere CR was 24%, 52%, 55%, and 67% for NO-SC, MC-SC, DCNN-SC, and TRUE-SC, respectively. For the liver phantom, the average CR for liver inserts were 32%, 73%, and 65% for NO-SC, MC-SC, and DCNN-SC, respectively while the corresponding values for average contrast-to-noise ratio (visibility index) in low-concentration extra-hepatic inserts were 2, 19, and 61, respectively. In patients, there was high concordance between lesion-to-liver uptake ratios for SPECT reconstruction with DCNN-SC (median 4.8, range 0.02-13.8) compared with MC-SC (median 4.0, range 0.13-12.1; CCC = 0.98) and with

conclusionsFor diverse

Indexed as

Image Processing, Computer-AssistedTomography, Emission-Computed, Single-PhotonHumansMonte Carlo MethodNeural Networks, ComputerPhantoms, Imaging90YConvolutional neural network (CNN)Deep learningMonte Carlo methodsRadioembolizationScatter correctionSPECT/CT

Identifiers

PMID32415551
PMCPMC7666660
OpenAlexW3025946345

What OpenQuestion holds

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LicenceTDM
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.