Evidence map›Paper›PMID 32415492›Full record

ArticleEJNMMI physics2020

Impact of dead time on quantitative

Alessandro Desy, Guillaume F Bouvet, Andrea Frezza, Philippe Després, Jean-Mathieu Beauregard

Open access · goldAbstract read
In one paragraph

Article in EJNMMI physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Dosimetry in Clinical Radiopharmaceutical Therapy of Cancer: Practicality Versus Perfection in Current Practice.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Review
  7. Article
  8. Feasibility of Single-Time-Point Dosimetry for Radiopharmaceutical Therapies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alessandro DesyCancer Research Centre and Department of Radiology and Nuclear Medicine, Université Laval, Quebec City, Canada.
Guillaume F BouvetCancer Research Centre and Department of Radiology and Nuclear Medicine, Université Laval, Quebec City, Canada.
Andrea FrezzaCancer Research Centre and Department of Physics, Engineering Physics and Optics, Université Laval, Quebec City, QC, Canada.
Philippe DesprésCancer Research Centre and Department of Physics, Engineering Physics and Optics, Université Laval, Quebec City, QC, Canada.
Jean-Mathieu BeauregardCancer Research Centre and Department of Radiology and Nuclear Medicine, Université Laval, Quebec City, Canada. jean-mathieu.beauregard@chudequebec.ca.ORCID http://orcid.org/0000-0003-2123-145X
Hôtel-Dieu de Québec · CAUniversité Laval · CA

Funding

CIHR MOP-142233
6 · The paper itself

Abstract

backgroundDead time may affect the accuracy of quantitative SPECT (QPSECT), and thus of dosimetry. The aim of this study was to quantify the effect of dead time on

methodsQSPECT/CT was performed on days 1 and 3 during 564 personalized

resultsThe probability to observe a larger dead time increased with the injected activity. A dead-time loss greater than 5% affected 14.4% and 5.7% of QSPECT scans performed at days 1 and 3, respectively. This resulted in renal absorbed dose estimates that would have been underestimated by more than 5% in 5.7% of cycles if no dead-time correction was applied, with a maximum underestimation of 22.1%. In the simulated empiric regime, this potential dose underestimation would have been limited to 6.2%.

conclusionDead-time correction improves the accuracy of dosimetry in

Indexed as

177LuDead timeDosimetryQuantitative SPECTRadionuclide therapy

Identifiers

PMID32415492
PMCPMC7229114
OpenAlexW3028415628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.