Evidence map›Paper›PMID 32415472›Full record

ArticleLa Radiologia medica2021

Short fractionation radiotherapy for early prostate cancer in the time of COVID-19: long-term excellent outcomes from a multicenter Italian trial suggest a larger adoption in clinical practice.

Salvina Barra, Alessia Guarnieri, Michela Buglione di Monale E Bastia, Michela Marcenaro, Elena Tornari, Liliana Belgioia, Stefano Maria Magrini, Umberto Ricardi, Renzo Corvò

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  8. Exploring Radiologists' Burnout in the COVID-19 Era: A Narrative Review.International journal of environmental research and public health · 2023
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  13. Immunotherapy Assessment: A New Paradigm for Radiologists.Diagnostics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Salvina BarraRadiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Alessia GuarnieriRadiation Oncology Department AO Città della Salute e della Scienza - Molinette, University of Turin, Turin, Italy.
Michela Buglione di Monale E BastiaRadiation Oncology Department, University and Spedali Civili of Brescia, Brescia, Italy.
Michela MarcenaroRadiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Elena TornariHealth Science Department (DISSAL), University of Genoa, Genoa, Italy.
Liliana BelgioiaRadiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy. liliana.belgioia@unige.it.ORCID http://orcid.org/0000-0003-0508-6344
Stefano Maria MagriniRadiation Oncology Department, University and Spedali Civili of Brescia, Brescia, Italy.
Umberto RicardiRadiation Oncology Department AO Città della Salute e della Scienza - Molinette, University of Turin, Turin, Italy.
Renzo CorvòRadiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Ospedale Policlinico San Martino · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Turin · ITUniversity of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo evaluate stereotactic body radiotherapy (SBRT) in low-risk Prostate Cancer patients as preferred treatment option in emergency health conditions. MATERIALS AND

methodsFrom April 2013 to September 2015, 28 patients with low-risk prostate cancer were prospectively enrolled. The SBRT prescribed dose was 36.25 Gy in 5 fractions, twice a week. Primary endpoints were acute and late toxicity. Secondary endpoints were biochemical recurrence free survival (bRFS) and overall survival.

resultsMedian follow-up was 65.5 months (range 52-81). No acute G3 or G4 toxicity was recorded. Acute G1 or G2 genitourinary (GU) toxicity occurred in 43% and acute G1-G2 gastrointestinal (GI) toxicity in 14%. Late G1 and G3 GU toxicity in 18% and 3.5%, respectively. The G3 toxicity was not directly attributable to radiotherapy. Late G1 GI toxicity occurred in 18%. 5yy bRFS was 96.5% (95% CI 82.3-99.4%).

conclusionsStereotactic body radiotherapy for early prostate cancer reported safe toxicity profile and a good clinical outcome at the median follow-up of 5 years. It may be an useful option if radiotherapy is required in emergency medical conditions.

Indexed as

RadiosurgeryAgedAged, 80 and overCone-Beam Computed TomographyCOVID-19Dose Fractionation, RadiationHumansItalyMaleMiddle AgedPandemicsProspective StudiesProstatic NeoplasmsSARS-CoV-2Tomography, X-Ray ComputedCOVID-19Hi-techHypofractionated radiotherapyProstate cancerSBRT

Identifiers

PMID32415472
PMCPMC7227177
OpenAlexW3025513071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.