ArticleSocial psychiatry and psychiatric epidemiology2021
A comprehensive model of predictors of quality of life in older adults with schizophrenia: results from the CSA study.
Article in Social psychiatry and psychiatric epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2022Pooled it
- Excess mortality and its causes among older adults with schizophrenia versus those with bipolar disorder and major depressive disorder: a 5-year prospective multicenter study.European archives of psychiatry and clinical neuroscience · 2025Article
- Parenthood and all-cause mortality in older adults with schizophrenia: a multicenter 5-year prospective study.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Long-term care utilization and all-cause mortality among older adults with major psychiatric disorders: a 5-year prospective multicenter study.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Acceptability and impact of computerised cognitive training on mental health and cognitive skills in schizophrenia: a double-blind controlled trial.General psychiatry · 2025Article
- Association of typical and atypical antipsychotics with mortality in older adults with schizophrenia: a 5-year multicenter prospective study.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Observational
- Exploring the interplay of psychiatric symptoms, antipsychotic medications, side effects, employment status, and quality of life in Chronic Schizophrenia.BMC psychiatry · 2024Article
- Digital Phenotyping in Adults with Schizophrenia: A Narrative Review.Current psychiatry reports · 2023Review
- Quality of life and its influencing factors in patients with schizophrenia.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- The 5-year outcome of subjective quality of life in older schizophrenia patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Association between FIASMA psychotropic medications and reduced risk of intubation or death in individuals with psychiatric disorders hospitalized for severe COVID-19: an observational multicenter study.Translational psychiatry · 2022Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
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Abstract
backgroundNumerous factors are known to influence quality of life of adults with schizophrenia. However, little is known regarding the potential predictors of quality of life in the increasing population of older adults with schizophrenia. The main objective of the present study was to propose a comprehensive model of quality of life in this specific population.
methodsData were derived from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) study, a large (N = 353) multicenter sample of older adults with schizophrenia or schizoaffective disorder recruited from French community mental-health teams. We used structural equation modeling to simultaneously examine the effects of six broad groups of clinical factors previously identified as potential predictors of quality of life in this population, including (1) severity of general psychopathology, (2) severity of depression, (3) severity of cognitive impairment, (4) psychotropic medications, (5) general medical conditions and (6) sociodemographic characteristics.
resultsGeneral psychopathology symptoms, and in particular negative and depressive symptoms, cognitive impairment, reduced overall functioning and low education were significantly and independently associated with diminished quality of life (all p < 0.05). Greater number of medical conditions and greater number of antipsychotics were also independently and negatively associated with quality of life, although these associations did not reach statistical significance in sensitivity analyses, possibly due to limited statistical power.
conclusionSeveral domains are implicated in quality of life among older adults with schizophrenia. Interventions targeting these factors may help improve importantly quality of life of this vulnerable population.
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