ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021
Association between continuous deep sedation and survival time in terminally ill cancer patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Family members' experiences of palliative sedation -a systematic integrative review.BMC palliative care · 2026Pooled it
- The experience of nurses when providing care across acts that may be perceived as death hastening: A qualitative evidence synthesis.Palliative medicine · 2025Pooled it
- Continuous sedation in adolescent and young adult cancer patients under home-based end-of-life care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- [New recommendations on palliative sedation].Schmerz (Berlin, Germany) · 2024Article
- Observational
- Comparison of survival times of advanced cancer patients with palliative care at home and in hospital.PloS one · 2023Article
- Current Status and Future Directions of Research on Palliative Sedation.Journal of hospice and palliative care · 2022Article
- Family experience of palliative sedation therapy: proportional vs. continuous deep sedation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Palliative Sedation-The Last Resort in Case of Difficult Symptom Control: A Narrative Review and Experiences from Palliative Care in Switzerland.Life (Basel, Switzerland) · 2022Review
- Characteristics Associated with Survival in Patients Receiving Continuous Deep Sedation in a Hospice Care Unit.Journal of hospice and palliative care · 2021Article
- Goods, causes and intentions: problems with applying the doctrine of double effect to palliative sedation.BMC medical ethics · 2021Article
- How to measure the effects and potential adverse events of palliative sedation? An integrative review.Palliative medicine · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOur study aimed to evaluate the association between CDS and survival time using the likelihood of receiving CDS to select a matched non-CDS group through an accurate measurement of survival time based on initiation of CDS.
methodsA retrospective cohort study was performed using an electronic database to collect data regarding terminally ill cancer patients admitted to a specialized palliative care unit from January 2012 to December 2016. We first used a Cox proportional hazard model with receiving CDS as the outcome to identify individuals with the highest plausibility of receiving CDS among the non-CDS group (n = 663). We then performed a multiple regression analysis comparing the CDS group (n = 311) and weighted non-CDS group (n = 311), using initiation of CDS (actual for the CDS group; estimated for the non-CDS group) as the starting time-point for measuring survival time.
resultsApproximately 32% of participants received CDS. The most common indications were delirium or agitation (58.2%), intractable pain (28.9%), and dyspnea (10.6%). Final multiple regression analysis revealed that survival time was longer in the CDS group than in the non-CDS group (Exp(β), 1.41; P < 0.001). Longer survival with CDS was more prominent in females, patients with renal dysfunction, and individuals with low C-reactive protein (CRP) or ferritin, compared with their counterpart subgroup.
conclusionsCDS was not associated with shortened survival; instead, it was associated with longer survival in our terminally ill cancer patients. Further studies in other populations are required to confirm or refute these findings.
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Registered trials
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