ArticleScientific reports2020
Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed, 113 citations in OpenAlex.
- Adaptive colistin resistance dynamics inMicrobiology spectrum · 2026Article
- Plasmid-borneOne health (Amsterdam, Netherlands) · 2026Article
- Global genomic and molecular epidemiology of carbapenem-resistant Enterobacter hormaechei.Communications biology · 2026Article
- Potential dissemination of IncHI2/IncHI2A plasmids carryingMicrobiology spectrum · 2026Article
- Genomic Insights Into Multidrug-Resistant FoodborneInternational journal of food science · 2026Article
- A novel self-transmissible mega plasmid from extensively drug-resistantCurrent research in microbial sciences · 2026Article
- Co-occurrence ofFrontiers in cellular and infection microbiology · 2026Article
- Emergence of transmissibleApplied and environmental microbiology · 2025Article
- Colistin resistance in the era of antimicrobial resistance: challenges and strategic countermeasures.Folia microbiologica · 2025Review
- Dissemination of a IncHI2A plasmid co-harboring the mcr-9 and blaAnnals of clinical microbiology and antimicrobials · 2025Article
- Article
- Study on collateral sensitivity of tigecycline to colistin-resistantMicrobiology spectrum · 2025Article
- Co-occurrence of mcr-9 and blaCurrent microbiology · 2025Article
- Insights into incompatible plasmids in multidrug-resistant Raoultella superbugs.BMC microbiology · 2025Article
- Dissemination of IncQ1 Plasmids Harboring NTEMicroorganisms · 2025Article
- Silent spread of mcr-9 in ESBL-producing Enterobacteriaceae clinical isolates, Jimma, Ethiopia.PloS one · 2025Article
- Insertion sequences inFrontiers in microbiology · 2025Article
- Polymyxin resistance in Enterobacter cloacae complex in Brazil: phenotypic and molecular characterization.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Emergence and transmission of the high-risk ST78 clone of OXA-48-producingEmerging microbes & infections · 2024Article
- Detection of mobile colistin resistance genesMicrobiology resource announcements · 2024Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence and spread of mobilized colistin resistance (mcr) genes have triggered extensive concerns worldwide. Here, we characterized the global distribution of mcr-9, a newly-identified variant of mcr, by assembling the data set of mcr-9-positive isolates from GenBank database and the literature available. Genetic features of all the mcr-9-harboring plasmids were determined by bioinformatic analysis. We showed that mcr-9 is globally distributed in 21 countries across six continents, with a wide dissemination among various species of Enterobacteriaceae strains from human, animal, food and environment. IncHI2-ST1 plasmids were found to be the predominant replicon type carrying mcr-9. Comparative genomics highlighted that IncHI2-type plasmids may also serve as a critical reservoir of mcr-9, from which different types of circulating plasmids acquired the mcr-9. Results revealed that the rcnR-rcnA-pcoE-pcoS-IS903-mcr-9-wbuC structure was consistent in most mcr-9 cassettes, suggesting a relatively unitary model involved in the mobilization of mcr-9. It is most likely that the spread of mcr-9 was mainly attributed to the conjugation and recombination events of mcr-9-carrying plasmids. In summary, our results provide a comprehensive picture of the distribution and genetic environment of mcr-9, and demonstrate the central roles played by IncHI2 plasmids in the worldwide dissemination of mcr-9.
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