Evidence map›Paper›PMID 32415113›Full record

ArticleNature communications2020

Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours.

Peter A Johansson, Kelly Brooks, Felicity Newell, Jane M Palmer, James S Wilmott, Antonia L Pritchard, Natasa Broit, Scott Wood, Matteo S Carlino, Conrad Leonard and 25 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 7 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 7 syntheses or guidelines pooled it, 139 citations in OpenAlex.

  1. Pooled it
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 11 institutions in 4 countries.

Peter A Johansson *QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Kelly Brooks *QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Felicity NewellQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Jane M PalmerQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-2702-522X
James S WilmottMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Antonia L PritchardQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Natasa BroitQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Scott WoodQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Matteo S CarlinoMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Conrad LeonardQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Lambros T KoufariotisQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Vaishnavi NathanQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-7201-6819
Aaron B BeasleySchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.ORCID http://orcid.org/0000-0001-5727-7463
Madeleine HowlieQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Rebecca DawsonQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Helen RizosMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-2094-9198
Chris W SchmidtQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-3955-5076
Georgina V LongMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Hayley HamiltonQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Jens F KiilgaardDepartment of Ophthalmology, Rigshospitalet-Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1054-1460
Timothy IsaacsPerth Retina, Perth, WA, Australia.
Elin S GraySchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.ORCID http://orcid.org/0000-0002-8613-3570
Olivia J RolfeQueensland Ocular Oncology Service, The Terrace Eye Centre, Brisbane, QLD, Australia.
John J ParkDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.
Andrew StarkQueensland Ocular Oncology Service, The Terrace Eye Centre, Brisbane, QLD, Australia.
Graham J MannMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Richard A ScolyerMelanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-8991-0013
John V PearsonQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Nicolas van BarenLudwig Institute for Cancer Research, Brussels, Belgium.
Nicola WaddellQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-3950-2476
Karin W WadtDepartment of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2882-6798
Lindsay A McGrathQueensland Ocular Oncology Service, The Terrace Eye Centre, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-0925-1124
Sunil K WarrierQueensland Ocular Oncology Service, The Terrace Eye Centre, Brisbane, QLD, Australia.
William GlassonQueensland Ocular Oncology Service, The Terrace Eye Centre, Brisbane, QLD, Australia.
Nicholas K HaywardQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. nick.hayward@qimrberghofer.edu.au.ORCID http://orcid.org/0000-0003-4760-1033
QIMR Berghofer Medical Research Institute · AUCity Eye Centre · AUThe University of Sydney · AUEdith Cowan University · AUThe University of Queensland · AUAustralian National University · AULudwig Cancer Research · BEMacquarie University · AURigshospitalet · DKThe University of Western Australia · AUUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% of patients progress to metastatic disease. Therapeutic options for metastatic UM are limited, with clinical trials having little impact. Here we perform whole-genome sequencing (WGS) of 103 UM from all sites of the uveal tract (choroid, ciliary body, iris). While most UM have low tumour mutation burden (TMB), two subsets with high TMB are seen; one driven by germline MBD4 mutation, and another by ultraviolet radiation (UVR) exposure, which is restricted to iris UM. All but one tumour have a known UM driver gene mutation (GNAQ, GNA11, BAP1, PLCB4, CYSLTR2, SF3B1, EIF1AX). We identify three other significantly mutated genes (TP53, RPL5 and CENPE).

Indexed as

Cell Line, TumorChromosome AberrationsComputational BiologyDisease-Free SurvivalDisease ProgressionDNA Mutational AnalysisGene DosageGenome, HumanGenomicsHumansIris NeoplasmsKaplan-Meier EstimateMarkov ChainsMelanocytesMelanomaMutationTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID32415113
PMCPMC7229209
OpenAlexW3025361106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.