Evidence map›Paper›PMID 32414951›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

Radiolabeled cCPE Peptides for SPECT Imaging of Claudin-4 Overexpression in Pancreatic Cancer.

Julia Baguña Torres, Michael Mosley, Sofia Koustoulidou, Samantha Hopkins, Stefan Knapp, Apirat Chaikuad, Masuo Kondoh, Keisuke Tachibana, Veerle Kersemans, Bart Cornelissen

Open access · hybridAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Targeting claudins in cancer.Nature reviews. Drug discovery · 2026
    Review
  2. Tight junction structure, assembly and (dys)function.Nature reviews. Molecular cell biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. The biology and pathogenicity ofMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Claudin-4: A New Molecular Target for Epithelial Cancer Therapy.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Targeting claudins in cancer: diagnosis, prognosis and therapy.American journal of cancer research · 2021
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Julia Baguña TorresCancer Research United Kingdom and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Michael MosleyCancer Research United Kingdom and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Sofia KoustoulidouCancer Research United Kingdom and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Samantha HopkinsCancer Research United Kingdom and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Stefan KnappInstitute of Pharmaceutical Chemistry and Structure Genomics Consortium, Goethe-University Frankfurt, Frankfurt am Main, Germany.
Apirat ChaikuadInstitute of Pharmaceutical Chemistry and Structure Genomics Consortium, Goethe-University Frankfurt, Frankfurt am Main, Germany.
Masuo KondohGraduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Osaka, Japan.
Keisuke TachibanaGraduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Osaka, Japan.
Veerle KersemansCancer Research United Kingdom and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
Bart CornelissenCancer Research United Kingdom and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom bart.cornelissen@oncology.ox.ac.uk.
University of Oxford · GBGoethe University Frankfurt · DEMedical Research Council · GBOsaka University · JP

Funding

Cancer Research UK 23970Medical Research Council
6 · The paper itself

Abstract

Overexpression of tight-junction protein claudin-4 has been detected in primary and metastatic pancreatic cancer tissue and is associated with better prognosis in patients. Noninvasive measurement of claudin-4 expression by imaging methods could provide a means for accelerating detection and stratifying patients into risk groups.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsCell Line, TumorCell Transformation, NeoplasticClaudin-4EnterotoxinsHumansIsotope LabelingMaleMiceMice, Inbred BALB CPancreatic NeoplasmsTomography, Emission-Computed, Single-PhotonClaudin-4enterotoxin, ClostridiumEnterotoxinsclaudin-4early diagnosispancreatic ductal adenocarcinomaSPECT imaging

Identifiers

PMID32414951
PMCPMC8679629
OpenAlexW3024732984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.