Evidence map›Paper›PMID 32414920›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Tibetan

Daisheng Song, Bradleigh E Navalsky, Wei Guan, Cassandra Ingersoll, Tao Wang, Emanuele Loro, Lydia Eeles, Kyle B Matchett, Melanie J Percy, John Walsby-Tickle and 6 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. High-altitude polycythemia: State-of-the-art review.Therapeutic advances in hematology · 2026
    Review
  7. Advances in Understanding Adaptive Hemoglobin Concentration at High Altitude.American journal of human biology : the official journal of the Human Biology Council · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Coexistence of Multiple Gene Variants in Some Patients with Erythrocytoses.Mediterranean journal of hematology and infectious diseases · 2024
    Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Daisheng SongDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-1960-8246
Bradleigh E NavalskyDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Wei GuanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Cassandra IngersollDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Tao WangPenn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Emanuele LoroDepartment of Physiology and Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Lydia EelesCentre for Experimental Medicine, School of Medicine, Dentistry, and Biomedical Science, Queen's University Belfast, BT12 6BA Belfast, United Kingdom.ORCID 0000-0002-1324-1036
Kyle B MatchettCentre for Cancer Research and Cell Biology, Queen's University Belfast, BT9 7AE Belfast, United Kingdom.ORCID 0000-0001-6148-6022
Melanie J PercyDepartment of Haematology, Belfast City Hospital, BT9 7AB Belfast, United Kingdom.
John Walsby-TickleChemistry Research Laboratory, Department of Chemistry, University of Oxford, OX1 3TA Oxford, United Kingdom.ORCID 0000-0002-1287-9580
James S O McCullaghChemistry Research Laboratory, Department of Chemistry, University of Oxford, OX1 3TA Oxford, United Kingdom.ORCID 0000-0003-4733-1205
Reinhold J MedinaCentre for Experimental Medicine, School of Medicine, Dentistry, and Biomedical Science, Queen's University Belfast, BT12 6BA Belfast, United Kingdom.
Tejvir S KhuranaDepartment of Physiology and Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Abigail W BighamDepartment of Anthropology, University of California, Los Angeles, CA 90095.ORCID 0000-0002-0109-5844
Terence R LappinCentre for Cancer Research and Cell Biology, Queen's University Belfast, BT9 7AE Belfast, United Kingdom.ORCID 0000-0002-0648-0223
Frank S LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; franklee@pennmedicine.upenn.edu.ORCID 0000-0003-2511-1834
University of Pennsylvania · USQueen's University Belfast · GBUniversity of Oxford · GBState Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing · CNUniversity of California, Los Angeles · USUniversity of Ulster · GB

Funding

Control of Erythropoiesis by the Oxygen Sensor PHD2R01DK104796 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LEE, FRANK S · 2015 to 2019
$1.8M
High Altitude Adaptation: A Model for Chronic HypoxiaR33HL120751 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LEE, FRANK S · 2016 to 2018
$1.5M
NHLBI NIH HHS R33 HL120751NIDDK NIH HHS R01 DK104796
6 · The paper itself

Abstract

Tibetans have adapted to the chronic hypoxia of high altitude and display a distinctive suite of physiologic adaptations, including augmented hypoxic ventilatory response and resistance to pulmonary hypertension. Genome-wide studies have consistently identified compelling genetic signatures of natural selection in two genes of the Hypoxia Inducible Factor pathway,

Indexed as

Adaptation, PhysiologicalLoss of Function MutationAllelesAltitudeAnimalsBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsEndothelial PAS Domain-Containing Protein 1HumansHypoxiaHypoxia-Inducible Factor-Proline DioxygenasesMiceMice, KnockoutPhenotypeSelection, GeneticTibetBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsEGLN1 protein, humanEgln1 protein, mouseEndothelial PAS Domain-Containing Protein 1Hypoxia-Inducible Factor-Proline Dioxygenasesprotein p23EGLN1EPAS1HIFhigh-altitude adaptationPHD2

Identifiers

PMID32414920
PMCPMC7275716
OpenAlexW3025776993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.