Evidence map›Paper›PMID 32414918›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Functional stability of water wire-carbonyl interactions in an ion channel.

Joana Paulino, Myunggi Yi, Ivan Hung, Zhehong Gan, Xiaoling Wang, Eduard Y Chekmenev, Huan-Xiang Zhou, Timothy A Cross

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Hydraulic Activation of the AsLOV2 Photoreceptor.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Expanding the Toolset of Biomolecular NMR with Efficient and Cost-EffectiveChemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  6. The journal of physical chemistry. A · 2024
    Article
  7. The journal of physical chemistry. B · 2024
    Review
  8. Article
  9. Article
  10. Characterization of peptide O⋯HN hydrogen bondsChemical communications (Cambridge, England) · 2023
    Article
  11. Magnetically aligned nanodiscs enable direct measurement ofJournal of magnetic resonance (San Diego, Calif. : 1997) · 2023
    Article
  12. Review
  13. Residue-Specific High-ResolutionThe journal of physical chemistry letters · 2022
    Article
  14. Article
  15. Article
  16. Solid-stateChemical science · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Chembiochem : a European journal of chemical biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Joana PaulinoNational High Magnetic Field Laboratory, Tallahassee, FL 32310.
Myunggi YiDepartment of Biomedical Engineering, Pukyong National University, 48513 Busan, South Korea.ORCID 0000-0003-4864-959X
Ivan HungNational High Magnetic Field Laboratory, Tallahassee, FL 32310.ORCID 0000-0001-8916-739X
Zhehong GanNational High Magnetic Field Laboratory, Tallahassee, FL 32310.
Xiaoling WangNational High Magnetic Field Laboratory, Tallahassee, FL 32310.
Eduard Y ChekmenevDepartment of Chemistry, Wayne State University, Detroit, MI 48201.ORCID 0000-0002-8745-8801
Huan-Xiang ZhouDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607.
Timothy A CrossNational High Magnetic Field Laboratory, Tallahassee, FL 32310; cross@magnet.fsu.edu.ORCID 0000-0002-9413-0505
National High Magnetic Field Laboratory · USFlorida State University · USPukyong National University · KRRussian Academy of Sciences · RUUniversity of Illinois Chicago · US

Funding

TR&D3-SCHP41GM122698 · NIGMS · FLORIDA STATE UNIVERSITY · PI BREY, WILLIAM W, CROSS, TIMOTHY A · 2017 to 2021
$6.7M
Quantitative, Mechanistic Studies of Biomolecular RecognitionR35GM118091 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Huan-Xiang Zhou · 2016 to 2026
$6.5M
DYNAMIC AND STRUCTURAL ELUCIDATION OF GRAMICIDIN A'R01AI023007 · NIAID · FLORIDA STATE UNIVERSITY · PI CROSS, TIMOTHY A · 1987 to 2014
$5.1M
Membrane Protein Structures and Interactions in the M. tuberculosis DivisomeR01AI119178 · NIAID · FLORIDA STATE UNIVERSITY · PI CROSS, TIMOTHY A · 2015 to 2019
$3.6M
NIAID NIH HHS R01 AI023007NIAID NIH HHS R01 AI119178NIGMS NIH HHS P41 GM122698NIGMS NIH HHS R35 GM118091
6 · The paper itself

Abstract

Water wires are critical for the functioning of many membrane proteins, as in channels that conduct water, protons, and other ions. Here, in liquid crystalline lipid bilayers under symmetric environmental conditions, the selective hydrogen bonding interactions between eight waters comprising a water wire and a subset of 26 carbonyl oxygens lining the antiparallel dimeric gramicidin A channel are characterized by

Indexed as

Binding SitesBiophysical PhenomenaCellular MicroenvironmentComputational BiologyGramicidinHydrogen BondingIon ChannelsLipid BilayersMagnetic Resonance SpectroscopyModels, MolecularOxygen IsotopesWaterGramicidinIon ChannelsLipid BilayersOxygen-17Oxygen IsotopesWater17O NMRgramicidin Amolecular dynamicsultra-high field NMRwater wire

Identifiers

PMID32414918
PMCPMC7275723
OpenAlexW3024982027

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.