ArticleProceedings of the National Academy of Sciences of the United States of America2020
Distinct activities of Scrib module proteins organize epithelial polarity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Fasciclin 2 Cooperates with Discs Large to Maintain Epithelial Architecture.bioRxiv : the preprint server for biology · 2026Article
- Basement membrane patterning by spatial deployment of a secretion-regulating protease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multisite polarity substrate Lgl.Nature structural & molecular biology · 2025Article
- Premature endocycling of Drosophila follicle cells causes pleiotropic defects in oogenesis.Genetics · 2024Article
- Mitochondrial morphology dynamics and ROS regulate apical polarity and differentiation in Drosophila follicle cells.Development (Cambridge, England) · 2024Article
- Compromised junctional integrity phenocopies age-dependent renal dysfunction in Drosophila Snakeskin mutants.Journal of cell science · 2023Article
- Coordination of tissue homeostasis and growth by the Scribble-α-Catenin-Septate junction complex.iScience · 2023Article
- WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition.Nature communications · 2022Article
- Apical-basal polarity and the control of epithelial form and function.Nature reviews. Molecular cell biology · 2022Review
- Minimal functional domains of the core polarity regulator Dlg.Biology open · 2022Article
- Juvenile hormone promotes paracellular transport of yolk proteins via remodeling zonula adherens at tricellular junctions in the follicular epithelium.PLoS genetics · 2022Article
- Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer.Communications biology · 2022Article
- Scribble and α-Catenin cooperatively regulate epithelial homeostasis and growth.Frontiers in cell and developmental biology · 2022Article
- Emerging Cnidarian Models for the Study of Epithelial Polarity.Frontiers in cell and developmental biology · 2022Review
- CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans.Genetics · 2021Article
- How cells tell up from down and stick together to construct multicellular tissues - interplay between apicobasal polarity and cell-cell adhesion.Journal of cell science · 2021Review
- Evidence for a nuclear role forMolecular biology of the cell · 2021Article
- Caenorhabditis elegans LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells.PLoS genetics · 2021Article
- Article
- Electrostatic plasma membrane targeting contributes to Dlg function in cell polarity and tumorigenesis.Development (Cambridge, England) · 2021Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
A polarized architecture is central to both epithelial structure and function. In many cells, polarity involves mutual antagonism between the Par complex and the Scribble (Scrib) module. While molecular mechanisms underlying Par-mediated apical determination are well-understood, how Scrib module proteins specify the basolateral domain remains unknown. Here, we demonstrate dependent and independent activities of Scrib, Discs-large (Dlg), and Lethal giant larvae (Lgl) using the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.