Evidence map›Paper›PMID 32414825›Full record

ArticleBMJ open2020

International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019.

Frédérique Chammartin, Cam Ha Dao Ostinelli, Kathryn Anastos, Antoine Jaquet, Ellen Brazier, Steven Brown, Francois Dabis, Mary-Ann Davies, Stephany N Duda, Karen Malateste and 4 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Initial Supplementary Dose of Dolutegravir in Second-Line Antiretroviral Therapy: A Noncomparative, Double-Blind, Randomized Placebo-Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
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  17. Drug Resistance in People With Viremia on Dolutegravir-based Antiretroviral Therapy in Sub-Saharan Africa: The DTG RESIST Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Frédérique ChammartinInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Cam Ha Dao OstinelliInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Kathryn AnastosDepartments of Medicine and Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Antoine JaquetFrench National Research Institute for Sustainable Development (IRD), Inserm, UMR 1219, University of Bordeaux, Bordeaux, France.
Ellen BrazierInstitute for Implementation Science in Population Health, City University of New York, New York, New York, USA.
Steven BrownDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Francois DabisFrench National Research Institute for Sustainable Development (IRD), Inserm, UMR 1219, University of Bordeaux, Bordeaux, France.
Mary-Ann DaviesCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Rondebosch, Western Cape, South Africa.
Stephany N DudaDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Karen MalatesteFrench National Research Institute for Sustainable Development (IRD), Inserm, UMR 1219, University of Bordeaux, Bordeaux, France.
Denis NashInstitute for Implementation Science in Population Health, City University of New York, New York, New York, USA.
Kara Wools-KaloustianDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Per M von GrooteInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Matthias EggerInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland matthias.egger@ispm.unibe.ch.ORCID 0000-0001-7462-5132
University of Bern · CHUniversité de Bordeaux · FRCity University of New York · USIndiana University School of MedicineAlbert Einstein College of Medicine · USUniversity of Cape Town · ZAVanderbilt University · US

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI AGGREY SEMWENDERO SEMEERE, Kara Kay Wools-Kaloustian · 2006 to 2026
$57.7M
Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
"Enhancing Cancer Research in Central Africa IeDEA"U01AI096299 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Denis Nash, Marcel Yotebieng · 2011 to 2026
$35.8M
WADA (West Africa Database on Antiretroviral Therapy) CollaborationU01AI069919 · NIAID · UNIVERSITY OF BORDEAUX II · PI Didier Koumavi Ekouevi, Antoine Jaquet · 2006 to 2026
$29.9M
Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research NetworksR24AI124872 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Stephany Norah Duda · 2016 to 2026
$12.5M
NIAID NIH HHS R24 AI124872NIAID NIH HHS U01 AI069911NIAID NIH HHS U01 AI069919NIAID NIH HHS U01 AI069924NIAID NIH HHS U01 AI096299
6 · The paper itself

Abstract

purposeThe objectives of the International epidemiology databases to evaluate AIDS (IeDEA) are to (i) evaluate the delivery of combination antiretroviral therapy (ART) in children, adolescents and adults in sub-Saharan Africa, (ii) to describe ART regimen effectiveness, durability and tolerability, (iii) to examine HIV-related comorbidities and coinfections and (iv) to examine the pregnancy-related and HIV-related outcomes of women on ART and their infants exposed to HIV or ART in utero or via breast milk.

participantsIeDEA is organised in four regions (Central, East, Southern and West Africa), with 240 treatment and care sites, six data centres at African, European and US universities, and almost 1.4 million children, adolescents and adult people living with HIV (PLWHIV) enrolled. FINDINGS TO DATE: The data include socio-demographic characteristics, clinical outcomes, opportunistic events, treatment regimens, clinic visits and laboratory measurements. They have been used to analyse outcomes in PLWHIV-1 or PLWHIV-2 who initiate ART, including determinants of mortality, of switching to second-line and third-line ART, drug resistance, loss to follow-up and the immunological and virological response to different ART regimens. Programme-level estimates of mortality have been corrected for loss to follow-up. We examined the impact of coinfection with hepatitis B and C, and the epidemiology of different cancers and of (multidrug resistant) tuberculosis, renal disease and of mental illness. The adoption of 'Treat All', making ART available to all PLWHIV regardless of CD4+ cell count or clinical stage was another important research topic. FUTURE PLANS: IeDEA has formulated several research priorities for the 'Treat All' era in sub-Saharan Africa. It recently obtained funding to set up sentinel sites where additional data are prospectively collected on cardiometabolic risks factors as well as mental health and liver diseases, and is planning to create a drug resistance database.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsAdolescentAdultAfrica South of the SaharaAfrica, WesternCD4 Lymphocyte CountChildFemaleHumansInfantPregnancyepidemiologyHIV & AIDSinfectious diseasestuberculosis

Identifiers

PMID32414825
PMCPMC7232622
OpenAlexW3025262438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.